Accession_ID	Standard Name	Systematic Name	Synonym	Full Name	Organism Common Name	Genus	Species	Description	Comment	DataSource	DataSource_Key
588	EB1			microtubule-associated protein		Dictyostelium				DDB	DDB0191160
2895	PLIP			phosphatidylinositol phosphatase		Dictyostelium				DDB	DDB0185057
2917	abcB1		mrpA	ABC transporter B family protein		Dictyostelium				DDB	DDB0201666
2920	abcB4			ABC transporter B family protein		Dictyostelium				DDB	DDB0208540
2921	abcB5			ABC transporter B family protein		Dictyostelium				DDB	DDB0201625
2970	abpA			actin binding protein,actin bundling protein,alpha actinin		Dictyostelium				DDB	DDB0191133
2972	abpD			actin binding protein,interaptin		Dictyostelium				DDB	DDB0191136
2985	act15		act3a;actin15;actinA1;actinIII-12;actinIII-12/A1	actin		Dictyostelium				DDB	DDB0185015
2987	act2		act2-1;actin2;actin2-sub1	actin		Dictyostelium				DDB	DDB0185124
2988	act17		act2-2;actin2;actin2sub-2;actin2sub2	actin		Dictyostelium				DDB	DDB0185125
2993	act6		actin6	actin		Dictyostelium				DDB	DDB0185126
2999	act16		actinM6	actin		Dictyostelium				DDB	DDB0185127
3020	apm2		AP2M2;DdApm1	AP-2 medium chain,AP-2 µ2,clathrin-adaptor medium chain		Dictyostelium				DDB	DDB0191267
3058	cbpA		CBP1	calcium-binding protein		Dictyostelium				DDB	DDB0185026
3100	culA			cullin		Dictyostelium				DDB	DDB0185191
3114	dagA		CRAC;synag7	PH domain-containing protein,cytosolic regulator of adenylate cyclase,cytosolic regulator of adenylyl cyclase		Dictyostelium				DDB	DDB0191434
3147	fbxA		chtA	F-Box A protein,cheaterA		Dictyostelium				DDB	DDB0185042
3171	gmsA			gamete and mating-type specific protein A		Dictyostelium				DDB	DDB0191145
3173	gpaA		Ga1;Galpha1;gpa1	G-protein subunit alpha 1		Dictyostelium				DDB	DDB0191255
3174	gpaB		Ga2;Galpha2;gpa2	G-protein subunit alpha 2		Dictyostelium				DDB	DDB0191327
3193	hspC		hsp32	heat shock protein		Dictyostelium				DDB	DDB0185048
3234	mlcE		EMLC	essential myosin light chain (ELC)		Dictyostelium				DDB	DDB0214813
3259	ndkC		gip17;NDK	NDP kinase,nucleoside diphosphate kinase		Dictyostelium				DDB	DDB0185051
3260	ndkM		NDK	NDP kinase,nucleoside diphosphate kinase		Dictyostelium				DDB	DDB0214817
3315	pspA		D19;psA;SP29	cell surface glycoprotein PsA precursor		Dictyostelium				DDB	DDB0191129
3383	sadA			substrate adhesion molecule		Dictyostelium				DDB	DDB0191090
3406	spnA		Spalten;Spn	protein serine/threonine phosphatase		Dictyostelium				DDB	DDB0185064
3460	α-Adaptin		&agr;;&agr; adaptin;&agr;-Ada;&agr;-Adaptin;ada;alpha;alpha adaptin;alpha-Ada;alpha-adaptin;AP-2;AP2;CG11994;CG31654;cg4260;CG7807;D-&agr;Ada;D-Ada;D-alphaAda;dADA;dAP-2;dAP-2&agr;;dAP-2a;DrosADA;l(2)06694;stummelbein	α-Adaptin	fruit fly	Drosophila	melanogaster	The D. melanogaster gene α-Adaptin is reported here. It has also been known in FlyBase as l(2)06694. It encodes a product involved in neurotransmitter secretion which is a component of the AP-2 adaptor complex. It has been sequenced and its amino acid sequence contains an alpha adaptin carboxyl-terminal domain. It has been mapped cytologically to 21C6. It interacts genetically with slbo, Chc and lqf. There are 10 recorded alleles: 9 classical mutants (1 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the synapse and are larval recessive lethal, conditional ts locomotor behavior defective, conditional ts uncoordinated, neurophysiology defective, neuroanatomy defective and conditional ts (with α-Adaptin4) visible. α-Adaptin is discussed in 55 references (excluding sequence accessions), dated between 1994 and 2003. These include at least 4 studies of mutant phenotypes and 4 molecular studies.		FB	FBgn0015567
3461	α-Cat		&agr;-CAT;&agr;-catenin;&agr;-ctn;&agr;cat;a-cat;alpha-Cat;alpha-catenin;alpha-ctn;alphacat;catenin;CG17947;CT39986;D&agr;-cadherin;D&agr;-cat;D&agr;-catenin;D&agr;C;D&agr;Catenin;D-&agr;-catenin;D-alpha-catenin;Dalpha-cadherin;Dalpha-cat;Dalpha-catenin;DalphaC;DalphaCatenin;Dmcatp	α Catenin	fruit fly	Drosophila	melanogaster	The D. melanogaster gene α Catenin, abbreviated as α-Cat, is reported here. It encodes a product with cadherin binding involved in oocyte positioning which is a component of the spot adherens junction. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 80E2--3. There are 6 recorded alleles: 5 in vitro constructs (none available from the public stock centers) and 1 wild-type. α-Cat is discussed in 96 references (excluding sequence accessions), dated between 1993 and 2003. These include at least one study of wild-type function and one molecular study.		FB	FBgn0010215
3462	α-Est1		&agr;-Est1;&agr;E1;A;aE1;alphaE1;Arc;bran;broad angular;CG1031;CG13505;CG6741;fragment A	α-Esterase-1	fruit fly	Drosophila	melanogaster	The D. melanogaster gene α-Esterase-1, abbreviated as α-Est1, is reported here. It encodes a product with carboxylesterase activity (EC:3.1.1.1). It has been sequenced and its amino acid sequence contains an esterase/lipase/thioesterase family active site and a carboxylesterases type-B. It has been mapped cytologically to 84D9. There is one recorded allele, which is wild-type. α-Est1 is discussed in 8 references (excluding sequence accessions), dated between 1996 and 2003. These include at least 3 molecular studies.		FB	FBgn0015568
3476	α-Man-I		&agr;-D-mannosidase;&agr;-Man-I;&agr;-mannosidase;2 mannosidase;alpha 1;alpha 1,2 mannosidase;alpha Mannosidase I;alpha-D-mannosidase;alpha-Man-I;alpha-Man-l;alpha-mannosidase;CG17809;CG18799;CG32684;DM-GI;MA12;Man'ase;MAN-1;mas-1	α Mannosidase I	fruit fly	Drosophila	melanogaster	The D. melanogaster gene α Mannosidase I, abbreviated as α-Man-I, is reported here. It has also been known in FlyBase as CG18799. It encodes a product with mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (EC:3.2.1.113) involved in N-linked glycosylation which is a component of the Golgi membrane. It has been sequenced and its amino acid sequence contains a glycosyl hydrolase family 47. It has been mapped by recombination to 1-30.1 and cytologically to 9B5--7. There are 13 recorded alleles: 12 classical mutants (4 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the ommatidium, the interommatidial bristle and the peripheral nervous system. α-Man-I is discussed in 22 references (excluding sequence accessions), dated between 1992 and 2003. These include at least one study of mutant phenotypes and 2 molecular studies.		FB	FBgn0010338
3477	α-Man-II		&agr;-Man-II;&agr;-mannosidase 2;alpha-Man-II;alpha-mannosidase 2;alpha-mannosidase II;CG18474;CG18802;CG8139;dGMII;DM-GII.1;GMII;Golgi Man II;Golgi mannosidase II;MAN-2;mannosidase II	α Mannosidase II	fruit fly	Drosophila	melanogaster	The D. melanogaster gene α Mannosidase II, abbreviated as α-Man-II, is reported here. It has also been known in FlyBase as CG18474. It encodes a product with mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity (EC:3.2.1.114) involved in N-linked glycosylation which is a component of the endoplasmic reticulum. It has been sequenced and its amino acid sequence contains a glycosyl hydrolases family 38. It has been mapped cytologically to 85D15--16. There are 5 recorded alleles: 3 in vitro constructs (none available from the public stock centers), 1 classical mutant (not available from the public stock centers) and 1 wild-type. α-Man-II is discussed in 26 references (excluding sequence accessions), dated between 1992 and 2003. These include at least one study of mutant phenotypes and 2 molecular studies.		FB	FBgn0011740
3478	α-Man-IIb		&agr;-D-mannosidase;&agr;-Man-IIb;&agr;-mannosidase;&agr;-mannosidase 2;alpha-D-mannosidase;alpha-M-II;alpha-mannosidase;alpha-mannosidase 2;CG4606;DM-GII.2;GTD#24/1;Man'ase;mannosidase II		fruit fly	Drosophila	melanogaster	The D. melanogaster gene α-Man-IIb is reported here. It encodes a product with alpha-mannosidase activity (EC:3.2.1.24) putatively involved in carbohydrate metabolism which is a component of the Golgi apparatus. It has been sequenced and its amino acid sequence contains a glycosyl hydrolases family 38. It has been mapped cytologically to 89A5. There are 3 recorded alleles: 2 classical mutants (1 available from the public stock centers) and 1 wild-type. Mutations have been isolated which are recessive lethal. α-Man-IIb is discussed in 14 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 3 molecular studies.		FB	FBgn0026616
3479	α-Spec		;&agr;;&agr; spectrin;&agr;-Spc;&agr;-Spec;&agr;-Spectrin;3A9;alpha;alpha spectrin;alpha-Spc;alpha-Spec;alpha-spectrin;alpha-spectrin II;anon-EST:fe2E2;anon-fast-evolving-2E2;CG1977;dre3;l(3)&agr;-Spec;l(3)04276;l(3)62Bd;l(3)alpha-Spec;l(3)dre3;spectrin	α Spectrin	fruit fly	Drosophila	melanogaster	The D. melanogaster gene α Spectrin, abbreviated as α-Spec, is reported here. It has also been known in FlyBase as anon-EST:fe2E2 and anon-fe2E2. It encodes a product with actin binding involved in oocyte construction which is a component of the spectrosome. It has been sequenced and its amino acid sequence contains a EF-hand family. It has been mapped cytologically to 62B4. There are 24 recorded alleles: 8 in vitro constructs (none available from the public stock centers), 15 classical mutants (none available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the cuprophilic cell, the midgut interstitial cell, the germ-line clone germline cyst and 9 other listed tissues and are larval recessive lethal, somatic clone female sterile, somatic clone mitotic, recessive hypoactive and neurophysiology defective. α-Spec is discussed in 191 references (excluding sequence accessions), dated between 1987 and 2003. These include at least 2 studies of mutant phenotypes, 5 studies of wild-type function and 8 molecular studies. Among findings on α-Spec function, α-Spec is required for ovarian follicle monolayer integrity.		FB	FBgn0003470
3480	αCop		&agr;-COP;&agr;Cop;alpha-COP;alphaCop;CG7961	α-coatomer protein	fruit fly	Drosophila	melanogaster	The D. melanogaster gene α-coatomer protein, abbreviated as αCop, is reported here. It encodes a product involved in retrograde transport, Golgi to ER which is a component of the COPI vesicle coat. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 62A12. There is one recorded allele, which is wild-type. αCop is discussed in 7 references (excluding sequence accessions), dated between 1998 and 2003. These include at least 2 molecular studies.		FB	FBgn0025725
3481	αPS4		&agr;-ps4;&agr;PS4;alphaPS4;CG16827;CT37393		fruit fly	Drosophila	melanogaster	The D. melanogaster gene αPS4 is reported here. It has also been known in FlyBase as CG16827. It encodes a product with receptor activity involved in heterophilic cell adhesion which is a component of the integrin complex. It has been sequenced and its amino acid sequence contains an integrins α chain. It has been mapped cytologically to 51E11. There is one recorded allele, which is wild-type. αPS4 is discussed in 11 references (excluding sequence accessions), dated between 1999 and 2003.		FB	FBgn0034005
3482	αPS5		&agr;PS5;alphaPS5;CG5372;CT17068		fruit fly	Drosophila	melanogaster	The D. melanogaster gene αPS5 is reported here. It has also been known in FlyBase as CG5372. It encodes a product with receptor activity involved in heterophilic cell adhesion which is a component of the integrin complex. It has been sequenced and its amino acid sequence contains an integrins α chain. It has been mapped cytologically to 59E4. There is one recorded allele, which is wild-type. αPS5 is discussed in 11 references (excluding sequence accessions), dated between 1999 and 2003.		FB	FBgn0034880
3484	&alpha;Tub67C		&agr; tubulin;&agr;-Tub;&agr;-Tub67C;&agr;-Tubulin;&agr;4;&agr;4-t;&agr;4-tubulin;&agr;4t;&agr;67C;&agr;TUB;&agr;Tub4;&agr;tub67C;&agr;Tub<up>67C</up>;&agr;tubulin;&mgr;m-tub67C;4t;ALPHA 6;ALPHA 67C;alpha tubulin;alpha tubulin 67C;alpha-tubulin;alpha4;alpha4-t;alpha4-tubulin;alpha4Tub67C;alpha67C;alphaTub67C;alphatubulin;alphaTub[67C];anon-EST:fe1F6;anon-fast-evolving-1F6;aTub67C;barbu;Bbu;bbu/tom;CG5185;CG8308;D.m.ALPHA-67C;DTA2;Fs(3)Sz22;Fs(3)Tom;Fs(3)Tomaj;T;Tom;Tomaj;tubulin	&alpha;-Tubulin at 67C	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &alpha;-Tubulin at 67C, abbreviated as &alpha;Tub67C, is reported here. It encodes a product with GTP binding involved in female pronucleus formation which is a component of the microtubule. It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 3-32.26 and cytologically to 67C4. It interacts genetically with &alpha;Tub84B, &alpha;Tub84D, ncd and nod. There are 25 recorded alleles: 3 in vitro constructs (none available from the public stock centers), 21 classical mutants (3 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the female pronucleus and are recessive female sterile, (with &alpha;Tub67C1 to 2) female sterile and dominant meiotic. &alpha;Tub67C is discussed in 106 references (excluding sequence accessions), dated between 1980 and 2003. These include at least 6 studies of mutant phenotypes, 3 studies of wild-type function and one molecular study. Among findings on &alpha;Tub67C mutants, mutations in &alpha;Tub67C specifically impair achiasmate segregation. Among findings on &alpha;Tub67C function, the &alpha;Tub67C gene product is involved in the formation of the sperm aster, cleavage spindle apparatus formation or function and the differentiation of the embryonic nervous system.		FB	FBgn0004236
3485	&alpha;Tub84B		;&agr; tubulin;&agr;-Tub;&agr;-Tub84B;&agr;-Tubulin;&agr;1;&agr;1 tubulin;&agr;1-tubulin;&agr;1t;&agr;1tub;&agr;84B;&agr;T;&agr;t-1;&agr;Tub;&agr;Tub1;&agr;Tub84B;&agr;tubulin;1t;a1t;ALPHA 84C;alpha tubulin;alpha-tubulin;alpha1;alpha1 tubulin;alpha1-tubulin;alpha1t;alpha84B;alphaT;alphat-1;alphaTub;alphaTub84B;alphatubulin;anon-EST:Liang-1.59;anon-EST:Liang-2.30;aTub84B;BEST:LD32507;CG1913;clone 1.59;clone 2.30;DM1&agr;;DTA1;l(3)84Bd;l(3)g3;ms(3)nc33;nc33;T;T&agr;1;Talpha1;Tub&agr;1;tubA84B;Tubalpha1;tubulin;tubulin &agr;1;Tubulin 1 &agr;-chain;tubulin 1&agr;;Tubulin-&agr;1;Tubulin-alpha1	&alpha;-Tubulin at 84B	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &alpha;-Tubulin at 84B, abbreviated as &alpha;Tub84B, is reported here. It encodes a product with GTP binding putatively involved in cell motility which is a component of the microtubule. It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 3-47.7 and cytologically to 84B4. It interacts genetically with &beta;Tub85D, &alpha;Tub67C and &alpha;Tub84D. There are 30 recorded alleles: 21 in vitro constructs (1 available from the public stock centers), 8 classical mutants (2 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which are lethal. &alpha;Tub84B is discussed in 145 references (excluding sequence accessions), dated between 1980 and 2003. These include at least 4 studies of mutant phenotypes, 6 studies of wild-type function and 2 molecular studies. Among findings on &alpha;Tub84B function, &alpha;Tub84B staining is used to analyze microtubule configuration during the first division of the zygote to investigate the organization of the first cleavage spindle and the origin of the functional centrosome.		FB	FBgn0003884
3486	&alpha;Tub84D		&agr; tubulin;&agr;-Tub;&agr;-Tub84D;&agr;-Tubulin;&agr;3;&agr;3t;&agr;84D;&agr;TUB;&agr;Tub3;&agr;Tub84D;&agr;tubulin;3t;ALPHA 84D;alpha tubulin;alpha-Tub;alpha-Tub84D;alpha-tubulin;alpha3;alpha3t;alpha84D;alphaTUB;alphaTub3;alphaTub84D;alphatubulin;aTub84D;CG2512;D.m.ALPHA-84D;DTA4;T;tubulin;tubulin &agr;3;tubulin alpha3	&alpha;-Tubulin at 84D	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &alpha;-Tubulin at 84D, abbreviated as &alpha;Tub84D, is reported here. It encodes a product with GTP binding putatively involved in microtubule-based process which is a component of the microtubule. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 84D9. It interacts genetically with &alpha;Tub67C and &alpha;Tub84B. There is one recorded allele, which is wild-type. &alpha;Tub84D is discussed in 86 references (excluding sequence accessions), dated between 1980 and 2003. These include at least one study of wild-type function and 2 molecular studies.		FB	FBgn0003885
3487	&alpha;Tub85E		&agr; tubulin;&agr;-Tub85E;&agr;-Tubulin;&agr;2;&agr;2-tubulin;&agr;2t;&agr;2tubulin;&agr;85E;&agr;85E-tubulin;&agr;Tub2;&agr;Tub84E;&agr;Tub85E;&agr;tubulin;2t;a2t;ALPHA 85E;alpha tubulin;alpha-Tub85E;alpha-tubulin;alpha2;alpha2-tubulin;alpha2t;alpha2tubulin;alpha85E;alpha85E-tubulin;alphaTub2;alphaTub84E;alphatubulin;aTub85E;CG9476;DTA3;T	&alpha;-Tubulin at 85E	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &alpha;-Tubulin at 85E, abbreviated as &alpha;Tub85E, is reported here. It encodes a product with GTP binding putatively involved in cell motility which is a component of the microtubule. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 85E6. There are 3 recorded alleles: 1 in vitro construct (not available from the public stock centers), 1 classical mutant (not available from the public stock centers) and 1 wild-type. &alpha;Tub85E is discussed in 73 references (excluding sequence accessions), dated between 1980 and 2003. These include at least one study of mutant phenotypes, 2 studies of wild-type function and 2 molecular studies.		FB	FBgn0003886
3488	&beta;'Cop		&bgr;'Cop;beta'-COP;beta'Cop;CG6699;d&bgr;'COP;dbeta'COP	&beta;'-coatomer protein	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &beta;'-coatomer protein, abbreviated as &beta;'Cop, is reported here. It encodes a product involved in Golgi vesicle budding which is a component of the COPI vesicle coat. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 34B9. There is one recorded allele, which is wild-type. &beta;'Cop is discussed in 9 references (excluding sequence accessions), dated between 1998 and 2003. These include at least 2 molecular studies.		FB	FBgn0025724
3490	&beta;-Spec		&bgr;;&bgr; spectrin;&bgr;-Spec;&bgr;-spectrin;&bgr;Spec;anon-EST:fe1B3;anon-fast-evol;anon-fast-evolving-1B3;b-Spec;beta;beta spectrin;beta-Spec;beta-spectrin;betaSpec;CG5870;i168;i6;l(1)G0074;l(1)G0108;l(1)G0198;Spec&bgr;;Spec-&bgr;;Spec-beta;SPEC8;Specbeta;spectrin	&beta; Spectrin	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &beta; Spectrin, abbreviated as &beta;-Spec, is reported here. It has also been known in FlyBase as anon-EST:fe1B3, anon-fe1B3, l(1)G0074, l(1)G0108 and l(1)G0198. It encodes a product with actin cross-linking activity involved in fusome organization and biogenesis which is a component of the spectrosome. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 16B10--12. There are 14 recorded alleles: 1 in vitro construct (not available from the public stock centers), 12 classical mutants (1 available from the public stock centers) and 1 wild-type. Mutations have been isolated which affect the embryonic larval midgut and are embryonic recessive lethal. &beta;-Spec is discussed in 92 references (excluding sequence accessions), dated between 1987 and 2003. These include at least 4 studies of mutant phenotypes, 3 studies of wild-type function and 3 molecular studies. Among findings on &beta;-Spec function, the distribution of &beta;-Spec product suggests roles in establishing an apicolateral membrane domain that is known to be rich in intercellular junctions and in establishing a unique membrane domain associated with contractile processes.		FB	FBgn0003471
3494	&beta;Cop		&bgr;-COP;&bgr;-CopII;&bgr;Cop;BcDNA.GH09317;BcDNA:GH09317;bcop;beta-COP;beta-CopII;BetaCop;CG6223	&beta;-coatomer protein	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &beta;-coatomer protein, abbreviated as &beta;Cop, is reported here. It has also been known in FlyBase as &beta;'Cop. It encodes a product involved in retrograde transport, Golgi to ER which is a component of the COPI vesicle coat. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 17A9. There are 5 recorded alleles: 4 in vitro constructs (none available from the public stock centers) and 1 wild-type. &beta;Cop is discussed in 18 references (excluding sequence accessions), dated between 1994 and 2003. These include at least one study of wild-type function and one molecular study.		FB	FBgn0008635
3497	&beta;Int-nu		&bgr;&ngr;;&Bgr;<down>&ngr;</down>;&bgr;<down>v</down>;&bgr;<up>&ngr;</up>-intergin;&bgr;Int-&ngr;;&bgr;Int<up>&ngr;</up>;&bgr;v;betaInt[nu];betanu;betav;Beta[[nu]];beta[[v]];CG1762;CT5192;integrin &bgr; v;integrin beta neu;Integrin bn	&beta;[nu] integrin	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &beta;&ngr; integrin, abbreviated as &beta;Int-&ngr;, is reported here. It has also been known in FlyBase as &beta;Int and &beta;Int&ngr;. It encodes a product with receptor activity involved in cell-matrix adhesion which is a component of the integrin complex. It has been sequenced and its amino acid sequence contains an integrins, &beta; chain and a PSI domain. It has been mapped cytologically to 39A1. There are 3 recorded alleles: 2 classical mutants (none available from the public stock centers) and 1 wild-type. &beta;Int-&ngr; is discussed in 18 references (excluding sequence accessions), dated between 1993 and 2003. These include at least 2 studies of mutant phenotypes and one molecular study. Among findings on &beta;Int-&ngr; mutants, embryos transheterozygous for deficiencies that remove &beta;Int-&ngr; develop a normal midgut.		FB	FBgn0010395
3499	&beta;Tub56D		;&bgr; tubulin;&bgr;-1-tubulin;&bgr;-tub;&bgr;-Tub56D;&bgr;-tubulin;&bgr;1;&bgr;1 tubulin;&bgr;1-tubulin;&bgr;1t;&bgr;1tub;&bgr;56D;&bgr;<down>1</down> tubulin;&bgr;<down>1</down>-tubulin;&bgr;Tub1;&bgr;Tub56D;&bgr;tubulin;1t;B1t;BETA 56D;beta tubulin;beta-1 tubulin;beta-1-tubulin;beta-tubulin;beta1;beta1 tubulin;beta1-tubulin;beta1t: beta1 tubulin;beta1Tub;beta56D;betaTub56D;beta[[1]] tubulin;beta[[1]]-tubulin;CG9277;Dm&bgr;1;Dmbeta1;DTB2;T;Tubulin	&beta;-Tubulin at 56D	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &beta;-Tubulin at 56D, abbreviated as &beta;Tub56D, is reported here. It encodes a product with structural constituent of cytoskeleton involved in muscle attachment which is a component of the microtubule. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 56D7--8. There are 7 recorded alleles: 4 in vitro constructs (none available from the public stock centers), 2 classical mutants (none available from the public stock centers) and 1 wild-type. Mutations have been isolated which are recessive lethal. &beta;Tub56D is discussed in 106 references (excluding sequence accessions), dated between 1982 and 2003. These include at least 10 studies of mutant phenotypes and one molecular study.		FB	FBgn0003887
3500	&beta;Tub60D		&bgr; tubulin;&bgr; Tubulin4;&bgr;-3tubulin;&bgr;-tub;&bgr;-Tub60D;&bgr;-Tub6D;&bgr;-tubulin;&bgr;3;&bgr;3 TU;&bgr;3 tubulin;&bgr;3-Tub;&bgr;3-tubulin;&bgr;3t;&bgr;3tubulin;&bgr;60C;&bgr;<down>3</down> tubulin;&bgr;<down>3</down>-Tub;&bgr;<down>3</down>-tubulin;&bgr;Tub3;&bgr;Tub60C;&bgr;Tub60D;3t;60C &bgr; tubulin;60C beta tubulin;B3-tubulin;B3t;beta 3 tubulin;BETA 60D;Beta tubulin;beta-3 Tubulin;beta-3tubulin;beta-tub;beta-tubulin;beta3;beta3 tubulin;beta3-tubulin;beta3t: beta3 tubulin;beta60C;betaTub60C;betaTub60D;beta[;beta[[3]] tubulin;beta[[3]]-tubulin;CG3401;D.m.BETA-60D;Dm&bgr;3;Dmbeta3;DTB3;p50;p50/tubulin;p53;p53/tubulin;T;tubulin;tubulin b-3	&beta;-Tubulin at 60D	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &beta;-Tubulin at 60D, abbreviated as &beta;Tub60D, is reported here. It encodes a product with GTP binding involved in axonogenesis which is a component of the microtubule. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 60C6. There are 21 recorded alleles: 6 in vitro constructs (none available from the public stock centers), 14 classical mutants (1 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the embryonic larval midgut and are recessive lethal, recessive phototaxis behavior defective and (with Df(2R)Px2) phototaxis behavior defective. &beta;Tub60D is discussed in 119 references (excluding sequence accessions), dated between 1980 and 2003. These include at least 2 studies of mutant phenotypes, 3 studies of wild-type function and 10 molecular studies. Among findings on &beta;Tub60D function, the expression of &beta;Tub60D in several embryonic sense organs makes sense of the behavioral defects of pre-lethal &beta;Tub60D mutant larvae.		FB	FBgn0003888
3501	&beta;Tub85D		&bgr; tubulin;&bgr;(2)Tu;&bgr;-tub;&bgr;-Tub85D;&bgr;-tubulin;&bgr;2;&bgr;2 tubulin;&bgr;2-tubulin;&bgr;2t;&bgr;2tub;&bgr;2tubulin;&bgr;85D;&bgr;<down>2</down>-tubulin;&bgr;Tub2;&bgr;Tub85D;2t;b2 tubulin;B2t;BETA 85D;beta tubulin;beta(2)Tu;beta-Tu;beta-tubulin;BETA2;beta2 tubulin;beta2-tubulin;beta2t;beta2tub;beta2tubulin;beta85D;betaTub85D;beta[[2]]-tubulin;CG9359;D.m.BETA-85D;Dm&bgr;2;Dmbeta2;DTB4;ms(3)KK<up>D</up>;testis-specific &bgr;-tubulin;tubulin	&beta;-Tubulin at 85D	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &beta;-Tubulin at 85D, abbreviated as &beta;Tub85D, is reported here. It encodes a product with GTP binding putatively involved in microtubule-based process which is a component of the microtubule. It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 3-48.5 and cytologically to 85D15. It interacts genetically with &alpha;Tub84B, wrl, hay, mrn, ms(3)nc3 and 3 other listed genes. There are 19 recorded alleles: 4 in vitro constructs (none available from the public stock centers), 14 classical mutants (6 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the microtubule, the testis, the spermatid axoneme and 2 other listed tissues and are recessive male sterile, (with &beta;Tub85Dn) male sterile and (with &beta;Tub85D8) male fertile. &beta;Tub85D is discussed in 95 references (excluding sequence accessions), dated between 1979 and 2003. These include at least 16 studies of mutant phenotypes, one study of wild-type function and 2 molecular studies.		FB	FBgn0003889
3502	&beta;Tub97EF		&bgr; tubulin;&bgr; Tubulin3;&bgr;-tub;&bgr;-Tub97EF;&bgr;-tubulin;&bgr;4 tubulin;&Bgr;4-tubulin;&bgr;4t;&bgr;97F;&bgr;Tub4;&bgr;Tub97EF;&bgr;Tub98BC;&bgr;Tub98C;&bgr;tubulin;4t;B4t;BETA 98B;beta tubulin;beta-Tub97EF;beta-tubulin;beta4 tubulin;Beta4-tubulin;beta4t: beta4 tubulin;beta97F;betaTub4;betaTub98BC;betaTub98C;betatubulin;CG4869;Dm&bgr;4;Dmbeta4;DTB1;T;tubulin	&beta;-Tubulin at 97EF	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &beta;-Tubulin at 97EF, abbreviated as &beta;Tub97EF, is reported here. It has also been known in FlyBase as CG4869. It encodes a product with putative structural constituent of cytoskeleton putatively involved in cell motility which is putatively a component of the microtubule. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 98B6--7. There is one recorded allele, which is wild-type. &beta;Tub97EF is discussed in 50 references (excluding sequence accessions), dated between 1982 and 2003. These include at least one molecular study.		FB	FBgn0003890
3503	&delta;-catenin		&dgr;-catenin;catenin;d-catenin;P120		fruit fly	Drosophila	melanogaster	The D. melanogaster gene &delta;-catenin is reported here. It encodes a product which is a component of the zonula adherens. There is one recorded allele, which is wild-type. &delta;-catenin is discussed in 3 references, dated between 2000 and 2003.		FB	FBgn0041583
3504	&delta;COP		&dgr;-Cop;&dgr;COP;63B12S;anon-WO03040301.246;Arch;Archain;ARCN1;CG14813;coatomer complex COPI delta-COP subunit;delta-coatomer protein;delta-Cop;DeltaCop;DM63B12S;EG:63B12.10;ESTS:63B12S;l(1)G0051;l(1)G0301;l(1)G0450	&delta;-coatomer protein	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &delta;-coatomer protein, abbreviated as &delta;COP, is reported here. It has also been known in FlyBase as Arch, CG14813, EG:63B12.10, ESTS63B12S, l(1)G0051, l(1)G0301 and l(1)G0450. It encodes a product involved in retrograde transport, Golgi to ER which is a component of the COPI vesicle coat. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 2B12--13. There are 6 recorded alleles: 2 in vitro constructs (none available from the public stock centers), 3 classical mutants (1 available from the public stock centers) and 1 wild-type. Mutations have been isolated which are recessive lethal. &delta;COP is discussed in 21 references (excluding sequence accessions), dated between 1994 and 2003. These include at least 3 molecular studies.		FB	FBgn0028969
3508	&gamma;Cop		&ggr;-COP;&ggr;Cop;anon-WO0118547.334;CG1528;copg;gamma-coatomer protein;gammaCop	&gamma;-coatomer protein	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &gamma;-coatomer protein, abbreviated as &gamma;Cop, is reported here. It encodes a product involved in retrograde transport, Golgi to ER which is a component of the COPI vesicle coat. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 100C6. There are 3 recorded alleles: 2 classical mutants (1 available from the public stock centers) and 1 wild-type. &gamma;Cop is discussed in 11 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 3 molecular studies.		FB	FBgn0028968
3512	&gamma;Tub23C		&ggr; tubulin;&ggr;-Tub;&ggr;-tub23;&ggr;-Tubulin;&ggr;-tubulin-1;&ggr;<up>zy</up>;&ggr;TUB;&ggr;tub23C;&ggr;Tub23CD;&ggr;tubulin;CG3157;D.m.GAMMA-23C;g-Tubulin;gama-tubulin;gamma tubulin;gamma-;gamma-tubulin;gamma-tubulin-1;GAMMA23C;gammatub;gammaTub23C;gammaTub23CD;gammatubulin;gamma[zy];GTUB	&gamma;-Tubulin at 23C	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &gamma;-Tubulin at 23C, abbreviated as &gamma;Tub23C, is reported here. It has also been known in FlyBase as &gamma;Tub23CD. It encodes a product with guanyl nucleotide binding involved in microtubule-based process which is a component of the microtubule. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 23C3--4. It interacts genetically with &gamma;Tub37C. There are 5 recorded alleles: 3 in vitro constructs (none available from the public stock centers), 1 classical mutant (not available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the larval brain, the imaginal disc and the spermatid and are larval recessive lethal and recessive mitotic. &gamma;Tub23C is discussed in 118 references (excluding sequence accessions), dated between 1989 and 2003. These include at least 8 studies of mutant phenotypes and 4 molecular studies.		FB	FBgn0004176
3513	&gamma;Tub37C		&g-Tub37C;&ggr; tubulin;&ggr; Tubulin2;&ggr;-Tub;&ggr;-Tubulin;&ggr;-tubulin-2;&ggr;<up>mat</up>;&ggr;TUB;&ggr;Tub2;&ggr;TUB37C;&ggr;Tub37CD;&ggr;tubulin;CG17566;D.m.GAMMA-37C;female sterile(2)Ted Wright 1;fs(2)TW1;fs(2)TWI;fsTW1;g-Tubulin;gama-tubulin;gamma;gamma Tub37CD;gamma tubulin;gamma-Tub;gamma-tubulin;gamma-tubulin-2;gammaTub37C;gammaTub37CD;gammatubulin;gamma[mat];maternal &ggr;-tubulin;PL10;Rb1011;TW1	&gamma;-Tubulin at 37C	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &gamma;-Tubulin at 37C, abbreviated as &gamma;Tub37C, is reported here. It has also been known in FlyBase as &gamma;Tub2 and fs(2)TW1. It encodes a product with putative structural constituent of cytoskeleton involved in microtubule-based process which is a component of the microtubule. It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 2-54 and cytologically to 37C7. It interacts genetically with E(&gamma;Tub37C1), ncd and &gamma;Tub23C. There are 20 recorded alleles: 2 in vitro constructs (none available from the public stock centers), 17 classical mutants (2 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the first meiotic metaphase, the cleavage, the spindle and 4 other listed tissues and are female sterile. &gamma;Tub37C is discussed in 126 references (excluding sequence accessions), dated between 1981 and 2003. These include at least 9 studies of mutant phenotypes, one study of wild-type function and 7 molecular studies. Among findings on &gamma;Tub37C mutants, mutations in &gamma;Tub37C show a maternal effect with defects in fertilization or very early embryonic development. Among findings on &gamma;Tub37C function, &gamma;Tub37C is essential for nuclear proliferation in the early embryo.		FB	FBgn0010097
3518	zetaCOP		&zgr;COP;CG3948;copz1;CT13124		fruit fly	Drosophila	melanogaster	The D. melanogaster gene &zgr;COP is reported here. It has also been known in FlyBase as CG3948. It encodes a product putatively involved in intracellular protein transport which is a component of the COPI vesicle coat. It has been sequenced and its amino acid sequence contains a clathrin adaptor complex, small chain. It has been mapped cytologically to 73B6. There is one recorded allele, which is wild-type. &zgr;COP is discussed in 6 references (excluding sequence accessions), dated between 1999 and 2003. These include at least one molecular study.		FB	FBgn0040512
3523	14-3-3epsilon		14-3-3;14-3-3&egr;;14-3-3-e;14-3-3e;anon-WO0172774.141;anon-WO02059370.52;CG31196;CT24092;d14-3-3&egr;;D14-3-3e;d14-3-3epsilon;EK3-5;l(3)j2B10;par-5;PAR5;SR3-9;Su(Raf)3B;Suppressor of Ras85D 3-9		fruit fly	Drosophila	melanogaster	The D. melanogaster gene 14-3-3&epsilon; is reported here. It has also been known in FlyBase as 14-3-3e, SR3-9, Su(Raf)3B, l(3)j2B10 and par-5. It encodes a product with diacylglycerol-activated/phospholipid dependent protein kinase C inhibitor activity involved in imaginal disc development which is a component of the ring canal (sensu Drosophila). It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 3-62.0 and cytologically to 90F10. It interacts genetically with phl, Ras85D, 14-3-3&zgr;, Dsor1, aop and 4 other listed genes. There are 10 recorded alleles: 9 classical mutants (2 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the embryonic maternal effect cuticle, the embryonic cycle 14, the germ-line clone oocyte and 3 other listed tissues and are larval recessive lethal, viable, recessive sterile, (with 14-3-3&epsilon;S-696) visible, recessive mitotic, recessive female sterile, (with Df(3R)P14) viable and (with Df(3R)P14) female sterile. 14-3-3&epsilon; is discussed in 44 references (excluding sequence accessions), dated between 1994 and 2003. These include at least 9 studies of mutant phenotypes and one study of wild-type function. Among findings on 14-3-3&epsilon; function, 14-3-3&epsilon; is required to time mitosis in undisturbed post-blastoderm cell cycles and to delay mitosis following irradiation in embryos.		FB	FBgn0020238
3524	14-3-3zeta		14-3-3;14-3-3&zgr;;2G1;4-3-3 zeta;5.11;549;BEST:GH05075;CG17870;Complementation group K;D14 3 3 protein;D14-3-3;D14-3-3&zgr;;D14-3-3: D14 3 3 protein;D14-3-3zeta;K;l(2)07103;l(2)46CFe;l(2)46Ee;leo;leo: leonardo;leonardo;leonardo 14-3-3;Leonardo-13-3-3;par-5;PAR5		fruit fly	Drosophila	melanogaster	The D. melanogaster gene 14-3-3&zgr; is reported here. It has also been known in FlyBase as 14-3-3, D14-3-3, l(2)07103, leo and par-5. It encodes a product with tryptophan hydroxylase activator activity involved in tryptophan hydroxylase activation which is a component of the ring canal (sensu Drosophila). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 46E6--8. It interacts genetically with 14-3-3&epsilon;, faf, tor and Src42A. There are 27 recorded alleles: 8 in vitro constructs (none available from the public stock centers), 18 classical mutants (1 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the embryonic lateral epidermis and the somatic clone follicle cell and are embryonic recessive lethal and neurophysiology defective. 14-3-3&zgr; is discussed in 85 references (excluding sequence accessions), dated between 1982 and 2003. These include at least 16 studies of mutant phenotypes, 3 studies of wild-type function and 5 molecular studies. Among findings on 14-3-3&zgr; function, both isoforms of the 14-3-3&zgr; gene are required acutely (as opposed to developmentally) for normal learning and memory.		FB	FBgn0004907
3526	18SrRNA		18S;18S rDNA;18S RNA;18S rRNA;18SRNA;BEST:GH11893;BEST:GH15369;BEST:LD10585;BEST:LD33742;BEST:LP07011;BEST:SD07466;NEST:bs01c01		fruit fly	Drosophila	melanogaster	The D. melanogaster multicopy gene 18SrRNA is reported here. It has also been known in FlyBase as 18SRNA. It encodes a product which is a component of the cytosolic small ribosomal subunit (sensu Eukarya). It has been sequenced. There is one recorded allele, which is wild-type. 18SrRNA is discussed in 15 references (excluding sequence accessions), dated between 1991 and 2003. These include at least one molecular study.		FB	FBgn0061475
3527	18w		18 Wheeler;18-Wheeler;18W;CG8896;CT25100;l(2)00053;tlr;tlr-2;toll;Toll like receptor;tolloid-related;wheeler	18 wheeler	fruit fly	Drosophila	melanogaster	The D. melanogaster gene 18 wheeler, abbreviated as 18w, is reported here. It encodes a product with transmembrane receptor activity involved in morphogenesis which is localized to the plasma membrane; it is expressed in the embryo (amnioproctodeal invagination, anal pad, anal plate, antennal sense organ and 17 other listed tissues). It has been sequenced and its amino acid sequence contains a TIR domain. It has been mapped cytologically to 56F8. There are 16 recorded alleles: 1 in vitro construct (not available from the public stock centers), 13 classical mutants (2 available from the public stock centers) and 2 wild-type. Loss-of-function mutations have been isolated which affect the leg, the antenna, the wing and the haltere and are larval recessive lethal. 18w is discussed in 66 references (excluding sequence accessions), dated between 1991 and 2003. These include at least 5 studies of mutant phenotypes, one study of wild-type function and 6 molecular studies. Among findings on 18w function, 18w is a critical component of the humoral immune response.		FB	FBgn0004364
3529	28SrRNA		28S;28S rDNA;28S ribosomal RNA;28S RNA;28S rRNA;28SRNA;BEST:HL02093;BEST:HL02977;BEST:HL03427;BEST:LD41653;NEST:bs10c09;NEST:bs15g08;NEST:bs17g11;NEST:bs30g02		fruit fly	Drosophila	melanogaster	The D. melanogaster multicopy gene 28SrRNA is reported here. It has also been known in FlyBase as 28SRNA. It encodes a product which is a component of the cytosolic large ribosomal subunit (sensu Eukarya). It has been sequenced. There is one recorded allele, which is wild-type. 28SrRNA is discussed in 22 references (excluding sequence accessions), dated between 1991 and 2003. These include at least one molecular study.		FB	FBgn0061474
3530	2SrRNA		2S rRNA;2SRNA;5.8S and 2S ribosomal rRNA		fruit fly	Drosophila	melanogaster	The D. melanogaster multicopy gene 2SrRNA is reported here. It encodes a product which is a component of the cytosolic large ribosomal subunit (sensu Eukarya). It has been sequenced. There is one recorded allele, which is wild-type. 2SrRNA is discussed in 5 references (excluding sequence accessions), dated between 1974 and 2003.		FB	FBgn0065042
3532	33-13				fruit fly	Drosophila	melanogaster	The D. melanogaster gene 33-13 is reported here. It encodes a product with DNA binding which is a component of the nucleus. It has been mapped cytologically to 65A1--6. There is one recorded allele, which is wild-type. 33-13 is discussed in 3 references, dated between 1998 and 2001.		FB	FBgn0024507
3534	5-HT1A		5-HT-dro2A;5-HT1ADro;5-HT<down>1ADro</down>;5-HT[[1ADro]];5HT-dro2A;5HT-drp<down>2A</down>;5HT-drp[[2A]];5HT-R2A;5HT-R2A: Serotonin receptor 2A;5HT1A;5HT<down>1ADro</down>;5htdro2a;CG16720;Dm5HTdro2A;DRO2A;Serotonin receptor 2A;serotonin-receptor-2A	Serotonin receptor 1A	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Serotonin receptor 1A, abbreviated as 5-HT1A, is reported here. It encodes a product with 5-HT1 receptor activity involved in serotonin receptor, phospholipase C activating pathway which is a component of the integral to plasma membrane; it is expressed in the embryo (VUM neuron, embryonic central nervous system and midline). It has been sequenced and its amino acid sequence contains a rhodopsin-like GPCR superfamily. It has been mapped cytologically to 56B2--5. There is one recorded allele, which is wild-type. 5-HT1A is discussed in 25 references (excluding sequence accessions), dated between 1991 and 2003. These include at least one study of wild-type function and 6 molecular studies.		FB	FBgn0004168
3535	5-HT1B		5-HT-dro2B;5-HT1BDro;5-HT<down>1BDro</down>;5-HT<down>dro2B</down>;5-HT[[1BDro]];5-HT[[dro2B]];5HT-dro2B;5HT-dro<down>2B</down>;5HT-dro[[2B]];5HT-R2B;5HT-R2B: Serotonin receptor 2B;5htdro2b;CG15113;Dm5HTdro2B;DRO2B;Serotonin receptor 2B	Serotonin receptor 1B	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Serotonin receptor 1B, abbreviated as 5-HT1B, is reported here. It encodes a product with serotonin receptor activity involved in serotonin receptor, phospholipase C activating pathway which is a component of the integral to plasma membrane; it is expressed in the embryo (bipolar dendrite neuron and ventral midline). It has been sequenced and its amino acid sequence contains a rhodopsin-like GPCR superfamily. It has been mapped cytologically to 56B1. There is one recorded allele, which is wild-type. 5-HT1B is discussed in 22 references (excluding sequence accessions), dated between 1991 and 2003. These include at least one study of wild-type function and one molecular study.		FB	FBgn0004572
3536	5-HT2		;5-HT2Dro;5-HT<down>2</down>;5-HT<down>2Dro</down>;5-HT[[2Dro]];5-HT[[2]];5HT-dro<down>1</down>;5HT-dro[[1]];5HT-R82A;5HT2-Dro;5HT2Dro;5HT<down>2Dro</down>;5HT[[2Dro]];CG1056;Dm5HT2	Serotonin receptor 2	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Serotonin receptor 2, abbreviated as 5-HT2, is reported here. It encodes a product with 5-HT2 receptor activity involved in serotonin receptor signaling pathway which is a component of the plasma membrane; it is expressed in the embryo (central nervous system). It has been sequenced and its amino acid sequence contains a rhodopsin-like GPCR superfamily. It has been mapped cytologically to 82C4--5. There are 4 recorded alleles: 3 in vitro constructs (none available from the public stock centers) and 1 wild-type. 5-HT2 is discussed in 27 references (excluding sequence accessions), dated between 1993 and 2003. These include at least 4 studies of wild-type function and 4 molecular studies. Among findings on 5-HT2 function, serotinin, acting through the 5-HT2 gene product, is necessary for proper gastrulation.		FB	FBgn0013743
3537	5-HT7		5-HT-dro;5-HT-dro1;5-HT7Dro;5-HT<down>7</down>;5-HT<down>7Dro</down>;5-HT<down>dro1</down>;5-HTdro1;5-HT[[7Dro]];5-HT[[7]];5-HT[[dro1]];5HT-dro;5HT-dro1;5HT-R1;5HT-R1: Serotonin receptor 1;5HT<down>7Dro</down>;5htdror;CG12073;Dm5HTdro1;DRO1;Serotonin receptor;Serotonin receptor 1	Serotonin receptor 7	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Serotonin receptor 7, abbreviated as 5-HT7, is reported here. It encodes a product with serotonin receptor activity involved in serotonin receptor signaling pathway which is a component of the integral to plasma membrane; it is expressed in the adult (adult head) and embryo (ventral midline). It has been sequenced and its amino acid sequence contains a rhodopsin-like GPCR superfamily. It has been mapped cytologically to 100B1. There is one recorded allele, which is wild-type. 5-HT7 is discussed in 22 references (excluding sequence accessions), dated between 1990 and 2003. These include at least one study of wild-type function and 4 molecular studies. Among findings on 5-HT7 function, 5-HT7 receptor stimulates adenylate cyclase.		FB	FBgn0004573
3539	5SrRNA		2S rRNA;5S;5S rDNA;5S RNA;5S rRNA;5S-rDNA;5SrDNA;5SRNA;Dm5S;l(2)03068;PZ03068;RNA X	5S ribosomal RNA	fruit fly	Drosophila	melanogaster	The D. melanogaster multicopy gene 5S ribosomal RNA, abbreviated as 5SrRNA, is reported here. It has also been known in FlyBase as 5SRNA and l(2)03068. It encodes a product which is a component of the cytosolic large ribosomal subunit (sensu Eukarya). It has been sequenced. It has been mapped cytologically to 56F1--2. There are 5 recorded alleles: 2 in vitro constructs (none available from the public stock centers), 2 classical mutants (1 available from the public stock centers) and 1 wild-type. Mutations have been isolated which are recessive semi-lethal and recessive lethal. 5SrRNA is discussed in 46 references (excluding sequence accessions), dated between 1970 and 2004. These include at least 3 studies of mutant phenotypes, one study of wild-type function and 2 molecular studies. Among findings on 5SrRNA mutants, point mutations introduced in vitro into pre-5SrRNA have been used to determine which regions of the pre-RNA are required for processing.		FB	FBgn0000002
3542	7SLRNA		;CR32864	RNA 7SL	fruit fly	Drosophila	melanogaster	The D. melanogaster RNA-encoding gene RNA 7SL, abbreviated as 7SLRNA, is reported here. It encodes a product putatively involved in SRP-dependent cotranslational membrane targeting which is putatively a component of the signal recognition particle. It has been sequenced. There is one recorded allele, which is wild-type. 7SLRNA is discussed in 3 references (excluding sequence accessions), dated between 1984 and 2002.		FB	FBgn0000003
3545	a		;Arc;bran;bran: broad angular;broad angular;CG13505;CG6741;E(sda)A	arc	fruit fly	Drosophila	melanogaster	The D. melanogaster gene arc, abbreviated as a, is reported here. It has also been known in FlyBase as CG13505 and CG6741. It encodes a product involved in eye morphogenesis (sensu Drosophila) which is localized to the adherens junction; it is expressed in the embryo (Malpighian tubule, embryonic/larval foregut, embryonic/larval hindgut, embryonic/larval salivary gland and posterior midgut primordium) and larva (morphogenetic furrow). It has been sequenced and its amino acid sequence contains a PDZ domain (also known as DHR or GLGF). It has been mapped by recombination to 2-99.2 and cytologically to 58C1--5. It interacts genetically with svr. There are 27 recorded alleles: 26 classical mutants (4 available from the public stock centers) and 1 wild-type. Mutations have been isolated which affect the wing and the crossvein and are recessive visible. a is discussed in 31 references (excluding sequence accessions), dated between 1919 and 2003. These include at least one study of mutant phenotypes, one study of wild-type function and 2 molecular studies. Among findings on a function, a may affect eye development by modulating adherens junctions of the developing ommatidia.		FB	FBgn0000008
3551	Aats-ala		;Alanyl-tRNA synthetase;AlaRS;alaS;ARS;CG13391;CG3017	Alanyl-tRNA synthetase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Alanyl-tRNA synthetase, abbreviated as Aats-ala, is reported here. It encodes a product with alanine-tRNA ligase activity (EC:6.1.1.7) involved in alanyl-tRNA aminoacylation which is expressed in the embryo (embryonic/larval salivary gland). It has been sequenced and its amino acid sequence contains an alanyl-tRNA synthetase and a DHHA1 domain. It has been mapped cytologically to 29B3. There are 2 recorded alleles: 1 classical mutant (available from the public stock centers) and 1 wild-type. Aats-ala is discussed in 9 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 3 molecular studies.		FB	FBgn0027094
3552	Aats-ala-m		;AlaS;CG4633;Dm mt AlaRS	mitochondrial alanyl-tRNA synthetase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene mitochondrial alanyl-tRNA synthetase, abbreviated as Aats-ala-m, is reported here. It encodes a product with alanine-tRNA ligase activity (EC:6.1.1.7) involved in alanyl-tRNA aminoacylation which is a component of the mitochondrion. It has been sequenced and its amino acid sequence contains an alanyl-tRNA synthetase. It has been mapped cytologically to 64C7. There is one recorded allele, which is wild-type. Aats-ala-m is discussed in 8 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 2 molecular studies.		FB	FBgn0028962
3562	Aats-leu		;CG7479;Leucyl-tRNA synthetase;LeuRS;LRS	Leucyl-tRNA synthetase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Leucyl-tRNA synthetase, abbreviated as Aats-leu, is reported here. It has also been known in FlyBase as CG7479. It encodes a product with leucine-tRNA ligase activity (EC:6.1.1.4) involved in leucyl-tRNA aminoacylation which is a component of the mitochondrial matrix. It has been sequenced and its amino acid sequence contains an aminoacyl-transfer RNA synthetases class-I, a t-RNA synthetase, class Ia and a leucyl-tRNA synthetase. It has been mapped cytologically to 64C1. There is one recorded allele, which is wild-type. Aats-leu is discussed in 9 references (excluding sequence accessions), dated between 1996 and 2003. These include at least 3 molecular studies.		FB	FBgn0027085
3564	Aats-met		;CG31322;CG8684;CG9612;Methionyl-tRNA synthetase;MetRS;MRS	Methionyl-tRNA synthetase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Methionyl-tRNA synthetase, abbreviated as Aats-met, is reported here. It has also been known in FlyBase as CG8684 and CG9612. It encodes a product with methionine-tRNA ligase activity (EC:6.1.1.10) involved in methionyl-tRNA aminoacylation which is a component of the mitochondrion. It has been sequenced and its amino acid sequence contains a t-RNA synthetase, class Ia and a methionyl-tRNA synthetase. It has been mapped cytologically to 88B1. There is one recorded allele, which is wild-type. Aats-met is discussed in 11 references (excluding sequence accessions), dated between 1996 and 2003. These include at least 3 molecular studies.		FB	FBgn0027083
3565	Aats-phe		3.2;CG13348;CG17962;DMZ60MEX;FRS;fruhstart;frustart;Phenylalanyl-tRNA synthetase;PheRS;Pts;z600	Phenylalanyl-tRNA synthetase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Phenylalanyl-tRNA synthetase, abbreviated as Aats-phe, is reported here. It encodes a product with phenylalanine-tRNA ligase activity (EC:6.1.1.20) involved in phenylalanyl-tRNA aminoacylation which is expressed in the embryo (embryonic/larval muscle system). It has been sequenced and its amino acid sequence contains an aminoacyl-transfer RNA synthetases class-II and a phenylalanyl-tRNA synthetase. It has been mapped cytologically to 50C20. There is one recorded allele, which is wild-type. Aats-phe is discussed in 10 references (excluding sequence accessions), dated between 1996 and 2003. These include at least 7 molecular studies.		FB	FBgn0020766
3566	Aats-phe-m		;mitochondrial phenylalanyl-tRNA synthetase;mtPheRS	mitochondrial phenylalanyl-tRNA synthetase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene mitochondrial phenylalanyl-tRNA synthetase, abbreviated as Aats-phe-m, is reported here. It has also been known in FlyBase as mt:Aats-phe. It encodes a product with phenylalanine-tRNA ligase activity (EC:6.1.1.20) involved in phenylalanyl-tRNA aminoacylation which is a component of the mitochondrion. There is one recorded allele, which is wild-type. Aats-phe-m is discussed in one reference, dating from 1999.		FB	FBgn0028548
3574	ab		;CG4807;clu;clu: clueless;clueless;l(2)k02807;parted;ptd	abrupt	fruit fly	Drosophila	melanogaster	The D. melanogaster gene abrupt, abbreviated as ab, is reported here. It has also been known in FlyBase as l(2)k02807. It encodes a product with specific RNA polymerase II transcription factor activity involved in axon choice point recognition which is localized to the nucleus; it is expressed in the embryo (VUM precursor, embryonic stomatogastric nervous system, epidermis, larval muscle system and ventral midline) and larva (dorsal mesothoracic disc, eye-antennal disc and imaginal disc). It has been sequenced and its amino acid sequence contains a BTB/POZ domain and a zinc finger, C2H2 type. It has been mapped by recombination to 2-44.0 and cytologically to 32E1--2. It interacts genetically with N and rho. There are 17 recorded alleles: 16 classical mutants (3 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the abdominal posterior fascicle, the abdominal transverse nerve, the abdominal 2 to 7 dorsal acute muscle 3 and 8 other listed tissues and are recessive male sterile. ab is discussed in 49 references (excluding sequence accessions), dated between 1925 and 2003. These include at least 5 studies of mutant phenotypes, one study of wild-type function and 5 molecular studies. Among findings on ab mutants, mutations in ab affect individual longitudinal veins: vein specific effects. Among findings on ab function, ab encodes a BTB-zinc finger regulatory protein that controls the specificity of neuromuscular connections.		FB	FBgn0000011
3576	abd-A		abd A;Abd-A;AbdA;abdominal-A;Cbxd;Cbxd: Contrabithoraxoid;CG10325;Contrabithoraxoid;DmabdA;Hab;Hab: Hyperabdominal;Hyperabdominal;i;iab;iab-2;iab-3;iab-4;iab-5;iab2;iab2: infra-abdominal 2;iab3;iab3: infra-abdominal 3;iab4;iab4: infra-abdominal 4;infra-abdominal 2;infra-abdominal 3;infra-abdominal 4;infraabdominal;jabanero;l(3)89Ec;Ultraabdominal	abdominal A	fruit fly	Drosophila	melanogaster	The D. melanogaster gene abdominal A, abbreviated as abd-A, is reported here. It encodes a product with specific RNA polymerase II transcription factor activity involved in oenocyte development which is localized to the nucleus; it is expressed in the embryo (ISN, abdominal 4-7 vental intersegmental neuron, amnioserosa, anterior and 18 other listed tissues) and larva (dorsal mesothoracic disc, female genital disc and male genital disc). It has been sequenced and its amino acid sequence contains a homeobox domain and a 'Homeobox' antennapedia-type domain. It has been mapped by recombination to 3-58.8 and cytologically to 89E2. It interacts genetically with su(Hw), Ubx, Abd-B, Dfd, lab and 5 other listed genes. There are 80 recorded alleles: 5 in vitro constructs (1 available from the public stock centers), 74 classical mutants (7 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the midgut constriction, the parasegment 7 to 9, the parasegment 10 to 13 and 11 other listed tissues and are homeotic recessive lethal. abd-A is discussed in 437 references (excluding sequence accessions), dated between 1963 and 2003. These include at least 20 studies of mutant phenotypes, 18 studies of wild-type function, 3 studies of natural polymorphisms and 49 molecular studies. Among findings on abd-A mutants, recessive mutations of the Hab group of abd-A alleles have been isolated as revertants of a dominant gain-of-function abd-A mutation. Among findings on abd-A function, a burst of abd-A expression in the postembryonic neuroblasts specifies the time at which apoptosis occurs, determining the number of progeny generated by each neuroblast. (However, there is much more information on function so that may not be representative.)		FB	FBgn0000014
3577	Abd-B		Abd B;ABDB;AbdB(CA)<down>26</down>;AbdB-I;AbdB-II;Abdominal-B;AdbB;CG10291;CG11648;DROABDB;FAB;Fab-7;Fab7;iab;iab-5;iab-6;iab-7;iab-8;iab5;iab5: infra-abdominal 5;iab6;iab6: infra-abdominal 6;iab7;iab7: infra-abdominal 7;iab8;iab8.9;iab8: infra-abdominal 8;iab9;iab9:;infra-abdominal 5;infra-abdominal 6;infra-abdominal 7;infra-abdominal 8;infra-abdominal 9;infraabdominal;infraabdominal-8.9;l(3)89Ed;Male chauvinist pigmentation;Mc;MCP;Mcp: Miscadastral pigmentation;Microcephalus;Miscadastral pigmentation;pH189;Sab;Sab: Superabdominal;Superabdominal;Tab;Tab: Transabdominal;Transabdominal;tuh-3;twig;Uab-5<up>Sab</up>	Abdominal B	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Abdominal B, abbreviated as Abd-B, is reported here. It has also been known in FlyBase as CG10291, CG11648, MS:AbdB.CA26, MS:DROABDB and Mc. It encodes a product with specific RNA polymerase II transcription factor activity involved in pigmentation which is localized to the nucleus; it is expressed in the embryo (Malpighian tubule, ectoderm, epidermis, parasegment 10 and 15 other listed tissues) and larva (female genital disc and male genital disc). It has been sequenced and its amino acid sequence contains a homeobox domain. It has been mapped by recombination to 3-58.8 and cytologically to 89E4--5. It interacts genetically with Pcl, tuh1, Ubx, Scm, ph-d and 15 other listed genes. There are 184 recorded alleles: 13 in vitro constructs (none available from the public stock centers), 170 classical mutants (12 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone abdominal segment 5 to 8, the embryonic somatic clone abdominal segment 8, the somatic clone sclerite and 9 other listed tissues and are dominant male sterile, dominant female sterile, recessive lethal, homeotic somatic clone visible, somatic clone (with Df(3R)P9) body color defective and (with Df(3R)P9) lethal. Abd-B is discussed in 490 references (excluding sequence accessions), dated between 1944 and 2003. These include at least 24 studies of mutant phenotypes, 18 studies of wild-type function, 4 studies of natural polymorphisms and 49 molecular studies. Among findings on Abd-B mutants, recessive Mcp group mutations of Abd-B have been isolated as revertants and partial revertants of dominant gain-of-function Abd-B alleles. Among findings on Abd-B function, Abd-B divides the primordium of the posterior spiracle into two cell populations that develop using distinct morphogenetic mechanisms into the spiracular chamber and the stigmatophore. (However, there is much more information on function so that may not be representative.)		FB	FBgn0000015
3579	Abl		4674;Abelson;abl;abl kinase;Abl oncogene;Abl1;Ableson;AblK;Am ABL;c-abl;cAbl;CG4032;D-abelson;D-abl;D-ash;DAbl;Dash;Ddash/abl;DROTKABL3;Dsrc7;l(3)04674;l(3)73B;l(3)73Ba;l(3)c-abl	Abl tyrosine kinase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Abl tyrosine kinase, abbreviated as Abl, is reported here. It has also been known in FlyBase as CG4032 and l(3)04674. It encodes a product with protein-tyrosine kinase activity (EC:2.7.1.112) involved in axon guidance which is localized to the axon; it is expressed in the embryo (embryonic central nervous system) and ovary (oocyte and ovary). It has been sequenced and its amino acid sequence contains an eukaryotic protein kinase, a src homology 2 (SH2) domain and a tyrosine kinase catalytic domain. It has been mapped cytologically to 73B1--4. It interacts genetically with ena, Dab, fax, Lar, robo and 15 other listed genes. There are 25 recorded alleles: 14 in vitro constructs (none available from the public stock centers), 10 classical mutants (3 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the central nervous system, the longitudinal connective, the commissure and 4 other listed tissues and are pupal recessive lethal, reduced (with Df(3L)st-j7) viable and neuroanatomy defective. Abl is discussed in 185 references (excluding sequence accessions), dated between 1981 and 2003. These include at least 27 studies of mutant phenotypes, 6 studies of wild-type function and 10 molecular studies. Among findings on Abl mutants, Abl mutants show phenotypes in somatic muscles and eye imaginal disks.		FB	FBgn0000017
3580	abo		;CG6093	abnormal oocyte	fruit fly	Drosophila	melanogaster	The D. melanogaster gene abnormal oocyte, abbreviated as abo, is reported here. It has also been known in FlyBase as CG6093. It encodes a product with transcription regulator activity involved in regulation of transcription from Pol II promoter which is a component of the polytene chromosome. It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 2-44.0 and cytologically to 32C1. It interacts genetically with ABO-X. There are 6 recorded alleles: 1 in vitro construct (not available from the public stock centers), 4 classical mutants (1 available from the public stock centers) and 1 wild-type. Mutations have been isolated which affect the extended germ band stage, the embryonic head and the embryonic cuticle and are female sterile and rescuable maternal effect lethal. abo is discussed in 39 references (excluding sequence accessions), dated between 1960 and 2003. These include at least 4 studies of mutant phenotypes, one study of wild-type function and 2 molecular studies. Among findings on abo mutants, maintained homozygous abo stocks show a decrease in maternally-induced embryonic lethality over time. Among findings on abo function, abo appears to be a negative regulator of histone transcription.		FB	FBgn0000018
3582	abs		ABS;abstract;anon-WO0118547.315;CG14637;DmRH23;l(3)00620;l(3)04505;l(3)06862;l(3)06863	abstrakt	fruit fly	Drosophila	melanogaster	The D. melanogaster gene abstrakt, abbreviated as abs, is reported here. It has also been known in FlyBase as l(3)00620. It encodes a product with ATP dependent helicase activity involved in establishment of cell polarity which is a component of the nucleus; it is expressed in the embryo (ubiquitous). It has been sequenced and its amino acid sequence contains a DEAD/DEAH box helicase, a helicase C-terminal domain and a zn-finger CCHC type. It has been mapped cytologically to 82A1. It interacts genetically with rpr. There are 21 recorded alleles: 4 in vitro constructs (none available from the public stock centers), 16 classical mutants (1 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the retina, the (with absE2) ommatidium, the ectopic (with absE2) photoreceptor cell and 2 other listed tissues and are larval (with absE2) lethal. abs is discussed in 19 references (excluding sequence accessions), dated between 1994 and 2003. These include at least one study of mutant phenotypes, 2 studies of wild-type function and 6 molecular studies. Among findings on abs function, abs is essential for survival at all stages throughout the life cycle.		FB	FBgn0015331
3583	ac		990 E5 F1;Ac;Ac: Argentine Curly;achaete-scute;AS-C T5;AS-C T5ac;ASC;ascT5;CG3796;EG:125H10.3;Hairy wing;Hairy-wing;Hw;Hw: Hairy-wing;sc/T5;T5	achaete	fruit fly	Drosophila	melanogaster	The D. melanogaster gene achaete, abbreviated as ac, is reported here. It encodes a product with DNA binding involved in neurogenesis which is localized to the nucleus; it is expressed in the embryo (cephalic furrow, ectoderm, embryonic central nervous system, embryonic peripheral nervous system and 16 other listed tissues) and larva (dorsal mesothoracic disc, ectoderm, proneural cluster, sensillum precursor and 2 other listed tissues). It has been sequenced and its amino acid sequence contains a helix-loop-helix dimerization domain and a myc-type, helix-loop-helix dimerization domain. It has been mapped by recombination to 1-0.0 and cytologically to 1A5--6. It interacts genetically with h, Oce, Egfr, su(sc), rho and 4 other listed genes. There are 37 recorded alleles: 15 in vitro constructs (none available from the public stock centers), 21 classical mutants (6 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the anterior dorsocentral bristle, the posterior dorsocentral bristle, the anterior supraalar bristle and 6 other listed tissues and are recessive visible. ac is discussed in 556 references (excluding sequence accessions), dated between 1918 and 2003. These include at least 72 studies of mutant phenotypes, one study of wild-type function, 6 studies of natural polymorphisms and 21 molecular studies.		FB	FBgn0000022
3589	Ace		AcChE;ACE;acetylcholinesterase;AChE;CG17907;CHE;dAChE;DmAChE;FBgn0000024;l(3)26;l(3)87Ed	Acetylcholine esterase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Acetylcholine esterase, abbreviated as Ace, is reported here. It encodes a product with acetylcholinesterase activity (EC:3.1.1.7) involved in response to carbamate which is a component of the plasma membrane. It has been sequenced and its amino acid sequence contains an esterase/lipase/thioesterase family active site, a cholinesterase, an insect acetylcholinesterase and a carboxylesterases type-B. It has been mapped by recombination to 3-52.5 and cytologically to 87E2--3. There are 61 recorded alleles: 15 in vitro constructs (none available from the public stock centers), 44 classical mutants (1 available from the public stock centers) and 2 wild-type. Loss-of-function mutations have been isolated which affect the somatic clone central nervous system and are embryonic recessive lethal, somatic clone optomotor behavior defective, somatic clone visual behavior defective and somatic clone courtship defective. Ace is discussed in 109 references (excluding sequence accessions), dated between 1964 and 2003. These include at least 10 studies of mutant phenotypes, one study of wild-type function and 9 molecular studies. Among findings on Ace function, in situ hybridization studies imply that the non-CNS-specific Ace can also be non-neuronal.		FB	FBgn0000024
3591	Acf1		ACF;Acf-1;ACF1;ATP-utilizing chromatin assembly and remodeling factor;CAF;CG1966;CHRAC;CHRAC-175;Chromatin Accessibility Complex;dACF;dCHRAC;p170/p185	ATP-dependent chromatin assembly factor large subunit	fruit fly	Drosophila	melanogaster	The D. melanogaster gene ATP-dependent chromatin assembly factor large subunit, abbreviated as Acf1, is reported here. It has also been known in FlyBase as Acf. It encodes a product with DNA binding involved in nucleosome spacing which is a component of the ACF complex. It has been sequenced and its amino acid sequence contains a PHD-finger. It has been mapped cytologically to 100D2. There are 3 recorded alleles: 2 classical mutants (1 available from the public stock centers) and 1 wild-type. Acf1 is discussed in 51 references (excluding sequence accessions), dated between 1997 and 2003. These include at least 2 studies of wild-type function and 2 molecular studies. Among findings on Acf1 function, in chromatin remodelling, Acf1 is able to modulate the internucleosomal spacing of chromatin by an ATP-dependent mechanism.		FB	FBgn0027620
3592	achi		;achintya;CG8819;zaa;zuker-aly-like a	achintya	fruit fly	Drosophila	melanogaster	The D. melanogaster gene achintya, abbreviated as achi, is reported here. It has also been known in FlyBase as CG8819, achintya and zaa. It encodes a product with transcription factor activity involved in spermatogenesis which is a component of the nucleus. It has been sequenced and its amino acid sequence contains a homeobox domain. It has been mapped by recombination to 2-65.5 and cytologically to 49A13--B1. There are 11 recorded alleles: 3 in vitro constructs (none available from the public stock centers), 7 classical mutants (1 available from the public stock centers) and 1 wild-type. Mutations have been isolated which are viable and partially male sterile. achi is discussed in 16 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 2 studies of wild-type function and 4 molecular studies. Among findings on achi function, achi is required during spermatogenesis.		FB	FBgn0033749
3597	acj6		Abnormal chemosensory jumb;ACJ6;CG9151;I-POU;Ipou;tI-POU;Twin of I-POU	abnormal chemosensory jump 6	fruit fly	Drosophila	melanogaster	The D. melanogaster gene abnormal chemosensory jump 6, abbreviated as acj6, is reported here. It has also been known in FlyBase as CG9151 and Ipou. It encodes a product with transcription corepressor activity involved in response to chemical substance which is a component of the nucleus; it is expressed in the embryo (CQ neuron, EL neuron, RP1 neuron, anterior corner cell and 4 other listed tissues). It has been sequenced and its amino acid sequence contains a 'POU' domain and a homeobox domain. It has been mapped by recombination to 1-49.4 and cytologically to 13B8--C1. It interacts genetically with vvl. There are 11 recorded alleles: 2 in vitro constructs (none available from the public stock centers), 8 classical mutants (none available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the antennal sensillum, the maxillary palp sense organ and the (with acj66) lamina plexus and are recessive chemosensitive behavior defective, recessive neurophysiology defective, larval behavioral, recessive olfaction defective, chemical sensitive, larval recessive locomotor behavior defective and adult (with acj66) locomotor behavior defective. acj6 is discussed in 60 references (excluding sequence accessions), dated between 1989 and 2003. These include at least 7 studies of mutant phenotypes, 2 studies of wild-type function and 3 molecular studies. Among findings on acj6 function, acj6 may regulate dendritic targeting and coordinate dendritic and axonal connectivity of projection neurons in the olfactory system to ensure the highly stereotypes acquisition and delivery of olfactory information by the central olfactory neurons.		FB	FBgn0000028
3603	Acon		;ACON-1;aconitase;AconM;BEST:GH10550;CG9244;FBgn0010100;i204;i59;l(2)07054;m-acon;m-Aconitase;mAc;mitochondrial aconitase	Aconitase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Aconitase, abbreviated as Acon, is reported here. It has also been known in FlyBase as CG9244 and l(2)07054. It encodes a product with aconitate hydratase activity (EC:4.2.1.3) putatively involved in amino acid biosynthesis which is a component of the mitochondrion. It has been sequenced and its amino acid sequence contains an aconitase C-terminal domain. It has been mapped cytologically to 39A7. There are 13 recorded alleles: 12 classical mutants (2 available from the public stock centers) and 1 wild-type. Mutations have been isolated which are recessive lethal. Acon is discussed in 22 references (excluding sequence accessions), dated between 1992 and 2003. These include at least 2 studies of mutant phenotypes and 2 molecular studies.		FB	FBgn0010100
3623	Act42A		42A actin.;A;act 42A;act42A;actin;BAP47;C;C: Group C;CG12051	Actin 42A	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Actin 42A, abbreviated as Act42A, is reported here. It encodes a product with putative structural constituent of cytoskeleton putatively involved in cytoskeleton organization and biogenesis which is a component of the actin filament; it is expressed in the embryo (embryonic/larval midgut, embryonic/larval proventriculus, gonad, supraesophageal ganglion and ventral nerve cord). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 42A4. There are 4 recorded alleles: 1 in vitro construct (not available from the public stock centers), 2 classical mutants (1 available from the public stock centers) and 1 wild-type. Act42A is discussed in 89 references (excluding sequence accessions), dated between 1980 and 2003. These include at least 2 studies of mutant phenotypes, one study of wild-type function and 7 molecular studies.		FB	FBgn0000043
3624	Act57B		act 57A;Act57A;Actin;anon-84Ea;anon-EST:CL2c12;BEST:RE38067;C;C: Group C;CG10067;CG2846;CG30294;M;M: M repeat;T10;transcript C	Actin 57B	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Actin 57B, abbreviated as Act57B, is reported here. It has also been known in FlyBase as Act57A, anon-EST:CL2c12 and anon-ESTCL2c12. It encodes a product with putative structural constituent of cytoskeleton involved in heart development which is a component of the actin filament; it is expressed in the embryo (larval muscle system and mesoderm) and larva (larval somatic muscle and pharyngeal muscle). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 57B5. There are 4 recorded alleles: 2 in vitro constructs (none available from the public stock centers), 1 classical mutant (not available from the public stock centers) and 1 wild-type. Mutations have been isolated which are larval (with Df(2R)E2) lethal. Act57B is discussed in 57 references (excluding sequence accessions), dated between 1980 and 2003. These include at least one study of mutant phenotypes, one study of wild-type function and 3 molecular studies.		FB	FBgn0000044
3625	Act5C		&bgr;-actin/Bap47;5C actin;A;Ac5C;act 5C;actin;actin 5C;actin A1;anon-EST:fe2D2;anon-fast-evolving-2D2;Bap47;CG4027;cyt5C;l(;l(1)G0009;l(1)G0010;l(1)G0025;l(1)G0079;l(1)G0117;l(1)G0177;l(1)G0245;l(1)G0330;l(1)G0420;l(1)G0486;M32055;T11	Actin 5C	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Actin 5C, abbreviated as Act5C, is reported here. It has also been known in FlyBase as l(1)G0009, l(1)G0010, l(1)G0025, l(1)G0079, l(1)G0117, l(1)G0177, l(1)G0245, l(1)G0330, l(1)G0420 and l(1)G0486. It encodes a product with putative structural constituent of cytoskeleton involved in sperm individualization which is a component of the actin filament; it is expressed in the embryo (anterior embryonic/larval midgut, embryonic central nervous system, posterior embryonic/larval midgut, subesophageal ganglion and 2 other listed tissues). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 5C7. There are 35 recorded alleles: 12 in vitro constructs (1 available from the public stock centers), 22 classical mutants (2 available from the public stock centers) and 1 wild-type. Mutations have been isolated which are larval lethal. Act5C is discussed in 171 references (excluding sequence accessions), dated between 1980 and 2003. These include at least 3 studies of mutant phenotypes, 3 studies of wild-type function, one study of natural polymorphisms and 12 molecular studies. Among findings on Act5C function, Act5C has a role in the individualization during spermatogenesis.		FB	FBgn0000042
3626	Act79B		79B Actin;act 79B;act79B;actin;CG5893;CG7478;D;mus79B	Actin 79B	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Actin 79B, abbreviated as Act79B, is reported here. It encodes a product with putative structural constituent of cytoskeleton putatively involved in cytoskeleton organization and biogenesis which is a component of the actin filament. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 79A6--7. There is one recorded allele, which is wild-type. Act79B is discussed in 54 references (excluding sequence accessions), dated between 1980 and 2003. These include at least 2 molecular studies.		FB	FBgn0000045
3627	Act87E		act 87E;Actin;CG18290;E;mus87E	Actin 87E	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Actin 87E, abbreviated as Act87E, is reported here. It has also been known in FlyBase as CG18290. It encodes a product with putative structural constituent of cytoskeleton putatively involved in cytoskeleton organization and biogenesis which is a component of the actin filament; it is expressed in the larva (larval muscle system). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 87E11. There is one recorded allele, which is wild-type. Act87E is discussed in 46 references (excluding sequence accessions), dated between 1980 and 2003. These include at least one study of natural polymorphisms and 7 molecular studies.		FB	FBgn0000046
3628	Act88F		88F actin;act 88F;Act(88F);Act88-F;actin;anon-EST:CL1a5;arthrin;BEST:LD10566;CG15026;CG32594;CG3331;CG5178;CG5530;E;E protein;Gene A;Ifm(3)7;rsd	Actin 88F	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Actin 88F, abbreviated as Act88F, is reported here. It encodes a product with putative structural constituent of cytoskeleton putatively involved in cytoskeleton organization and biogenesis which is a component of the actin filament. It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 3-57.1 and cytologically to 88F5. It interacts genetically with Mhc and fln. There are 81 recorded alleles: 41 in vitro constructs (none available from the public stock centers), 39 classical mutants (none available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the wing and are dominant flightless and recessive visible. Act88F is discussed in 138 references (excluding sequence accessions), dated between 1980 and 2003. These include at least 9 studies of mutant phenotypes, 2 studies of wild-type function, 2 studies of natural polymorphisms and 4 molecular studies. Among findings on Act88F function, Act88F functions in the leg and uterine muscles, though to a lower level than in the IFMs.		FB	FBgn0000047
3630	Actn		&agr;-Actinin;a-actinin;Alpha-actinin;CG3757;CG4376;CT14163;CT14232;EG:133E12.1;fliA;fliA: flightless-A;flightless A;flightless-A;GA17;HM-29;l(1)2Cb;l(1)EA82;lethal(1)2cb;y	&alpha; actinin	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &alpha; actinin, abbreviated as Actn, is reported here. It encodes a product with actin cross-linking activity putatively involved in cytoskeletal anchoring which is putatively a component of the focal adhesion. It has been sequenced and its amino acid sequence contains a phytochrome and a EF-hand family. It has been mapped cytologically to 2C4--7. It interacts genetically with wupA and vri. There are 25 recorded alleles: 24 classical mutants (4 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic muscle and are larval recessive lethal and larval recessive locomotor behavior defective. Actn is discussed in 64 references (excluding sequence accessions), dated between 1977 and 2003. These include at least 3 studies of mutant phenotypes, 2 studies of wild-type function and 8 molecular studies.		FB	FBgn0000667
3632	Actr13E		Acrp;actin-related protein;ARP;ARP(13E);Arp13E;Arp4;CG11678	Actin-related protein 13E	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Actin-related protein 13E, abbreviated as Actr13E, is reported here. It encodes a product with structural constituent of cytoskeleton putatively involved in cytoskeleton organization and biogenesis which is a component of the actin filament. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 13E12. There is one recorded allele, which is wild-type. Actr13E is discussed in 15 references (excluding sequence accessions), dated between 1992 and 2003. These include at least 2 molecular studies.		FB	FBgn0011741
3641	Ada2A		ADA2A;CG31318;CG7150;dAda2A		fruit fly	Drosophila	melanogaster	The D. melanogaster gene Ada2A is reported here. It has also been known in FlyBase as CG7150. It encodes a product with histone acetyltransferase activity (EC:2.3.1.48) putatively involved in regulation of transcription from Pol II promoter which is a component of the Ada2/Gcn5/Ada3 transcription activator complex. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 90F10--11. There is one recorded allele, which is wild-type. Ada2A is discussed in 9 references (excluding sequence accessions), dated between 1999 and 2003.		FB	FBgn0051318
3642	Ada2S		ADA2b;BcDNA:LD24527;CG9638;dAda2b;dAda2S;Transcriptional adapter 2S	Transcriptional adapter 2S	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Transcriptional adapter 2S, abbreviated as Ada2S, is reported here. It has also been known in FlyBase as CG9638. It encodes a product with histone acetyltransferase activity (EC:2.3.1.48) putatively involved in regulation of transcription from Pol II promoter which is a component of the SAGA complex. It has been sequenced and its amino acid sequence contains a myb DNA binding domain. It has been mapped cytologically to 84F5. There is one recorded allele, which is wild-type. Ada2S is discussed in 8 references (excluding sequence accessions), dated between 1999 and 2003. These include at least one molecular study.		FB	FBgn0037555
3649	Adf1		Adf 1;Adf-1;CG15845;l(2)01349;l(2)04065;nal;nalyot;naylot	Adh transcription factor 1	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Adh transcription factor 1, abbreviated as Adf1, is reported here. It has also been known in FlyBase as CG15845, l(2)01349, l(2)04065 and nal. It encodes a product with RNA polymerase II transcription factor activity involved in synaptogenesis which is localized to the nucleus. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 42C3. There are 41 recorded alleles: 30 in vitro constructs (none available from the public stock centers), 10 classical mutants (1 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the bouton and are recessive memory defective and neuroanatomy defective. Adf1 is discussed in 48 references (excluding sequence accessions), dated between 1985 and 2003. These include at least one study of wild-type function, one study of natural polymorphisms and 7 molecular studies. Among findings on Adf1 function, Adf1 may be a critical regulatory switch involved in terminal stages of synapse maturation.		FB	FBgn0000054
3658	Adk2		Adenylate kinase-2;ADK-2;anon-Dak2;BcDNA:SD09634;CG3140;Dak2	Adenylate kinase-2	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Adenylate kinase-2, abbreviated as Adk2, is reported here. It has also been known in FlyBase as BcDNA:SD09634, CG3140 and anon-Dak2. It encodes a product with adenylate kinase activity (EC:2.7.4.3) involved in ADP biosynthesis which is a component of the mitochondrial intermembrane space. It has been sequenced and its amino acid sequence contains an adenylate kinase. It has been mapped cytologically to 60B4. There are 2 recorded alleles: 1 classical mutant (not available from the public stock centers) and 1 wild-type. Adk2 is discussed in 16 references (excluding sequence accessions), dated between 1992 and 2003. These include at least 3 molecular studies.		FB	FBgn0022708
3660	Adk3		Adenylate kinase-3;AK3;bs12h03.y1;CG6612;DAK3	Adenylate kinase-3	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Adenylate kinase-3, abbreviated as Adk3, is reported here. It has also been known in FlyBase as CG6612. It encodes a product with adenylate kinase activity (EC:2.7.4.3) involved in ADP biosynthesis which is a component of the mitochondrial matrix. It has been sequenced and its amino acid sequence contains an adenylate kinase. It has been mapped cytologically to 86C7. There is one recorded allele, which is wild-type. Adk3 is discussed in 11 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 2 molecular studies.		FB	FBgn0042094
3664	Aef1		Adh enhancer factor 1;AEF-1;CG5683	Adult enhancer factor 1	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Adult enhancer factor 1, abbreviated as Aef1, is reported here. It encodes a product with RNA polymerase II transcription factor activity involved in negative regulation of transcription from Pol II promoter which is a component of the nucleus. It has been sequenced and its amino acid sequence contains a zinc finger, C2H2 type. It has been mapped cytologically to 78D2. There are 7 recorded alleles: 5 in vitro constructs (none available from the public stock centers), 1 classical mutant (available from the public stock centers) and 1 wild-type. Aef1 is discussed in 21 references (excluding sequence accessions), dated between 1992 and 2003. These include at least one study of wild-type function and one molecular study.		FB	FBgn0005694
3665	aft		adrift;CG5032;EG:52C10.7	adrift	fruit fly	Drosophila	melanogaster	The D. melanogaster gene adrift, abbreviated as aft, is reported here. It has also been known in FlyBase as EG:52C10.7 and adrift. It encodes a product involved in cell migration which is a component of the nucleus; it is expressed in the embryo (embryonic brain, embryonic/larval ganglionic branch, embryonic/larval tracheal system, epidermis and gonad). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 54E9. There are 6 recorded alleles: 2 in vitro constructs (none available from the public stock centers), 3 classical mutants (1 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the embryonic/larval ganglionic branch. aft is discussed in 10 references (excluding sequence accessions), dated between 1999 and 2003. These include at least one study of mutant phenotypes, one study of wild-type function and 4 molecular studies. Among findings on aft mutants, ganglionic tracheal branches migrate normally along the intersegmental nerve in aft mutants, but sporadically fail to switch to the segmental nerve and enter the central nervous system, instead they end up meandering along the ventral epidermis. Among findings on aft function, aft is required for tracheal pathfinding into the CNS.		FB	FBgn0026309
3671	ago		;anon-WO0118547.345;archipelago;cdc4;CG15010;DmFbw7;SCF<up>Ago</up>	archipelago	fruit fly	Drosophila	melanogaster	The D. melanogaster gene archipelago, abbreviated as ago, is reported here. It has also been known in FlyBase as CG15010. It encodes a product with ubiquitin-protein ligase activity (EC:6.3.2.19) involved in regulation of mitosis which is a component of the SCF ubiquitin ligase complex. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 64A11--12. It interacts genetically with dap and CycE. There are 13 recorded alleles: 8 in vitro constructs (none available from the public stock centers), 4 classical mutants (1 available from the public stock centers) and 1 wild-type. Mutations have been isolated which affect the ectopic somatic clone secondary pigment cell, the ectopic somatic clone tertiary pigment cell, the ectopic somatic clone interommatidial bristle and the somatic clone mitotic cycle and are somatic clone increased cell number and somatic clone mitotic. ago is discussed in 23 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 2 studies of mutant phenotypes, one study of wild-type function and one molecular study.		FB	FBgn0041171
3680	Akt1		AKT;AKT/PKB;CG4006;D-Akt;Dakt;dAKT/dPKB;dAkt/PKB;dakt1;DAKT1/PKB;DPKB;DRAC-PK;DRAC-PK66; DRAC-PK85;l(3)04226;l(3)89Bq;PKB;PKB/AKT;PKB/dAKT;RAC;RacPK;Related to PKA to;Related to PKA to PKC protein kinases;related to the A and C kinases		fruit fly	Drosophila	melanogaster	The D. melanogaster gene Akt1 is reported here. It has also been known in FlyBase as RacPK, l(3)04226 and l(3)89Bq. It encodes a product with protein serine/threonine kinase activity involved in positive regulation of cell size which is a component of the plasma membrane; it is expressed in the ovary (nurse cell). It has been sequenced and its amino acid sequence contains an eukaryotic protein kinase, a protein kinase C-terminal domain and a serine/Threonine protein kinase family active site. It has been mapped cytologically to 89B3. It interacts genetically with foxo, Pten, Thor, Pk61C, Pi3K92E and 4 other listed genes. There are 16 recorded alleles: 10 in vitro constructs (none available from the public stock centers), 5 classical mutants (1 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the germ-line clone maternal effect embryonic/first instar larval cuticle, the somatic clone rhabdomere, the somatic clone ommatidium and 3 other listed tissues and are recessive lethal, germ-line clone cell death increase, recessive somatic clone visible and somatic clone reduced cell size. Akt1 is discussed in 93 references (excluding sequence accessions), dated between 1992 and 2003. These include at least 14 studies of mutant phenotypes, one study of wild-type function and 7 molecular studies. Among findings on Akt1 function, data implicates Akt1 as a cell survival gene.		FB	FBgn0010379
3681	al		A1;AL;CG3935;L13-4;lambda13-4	aristaless	fruit fly	Drosophila	melanogaster	The D. melanogaster gene aristaless, abbreviated as al, is reported here. It encodes a product with specific RNA polymerase II transcription factor activity involved in proximal/distal pattern formation, imaginal disc which is a component of the nucleus; it is expressed in the embryo (embryonic abdominal segment 1 to 8, embryonic antennal segment, embryonic labial segment, embryonic mandibular segment and 4 other listed tissues) and larva (dorsal mesothoracic disc, eye-antennal disc and ventral thoracic disc). It has been sequenced and its amino acid sequence contains a helix-turn-helix / &lamda; and other repressors, a homeobox domain and a OAR domain. It has been mapped by recombination to 2-0.4 and cytologically to 21C2--4. It interacts genetically with ss, th, Antp and Lim1. There are 22 recorded alleles: 5 in vitro constructs (none available from the public stock centers), 16 classical mutants (3 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the arista, the posterior scutellar bristle, the scutellum and 6 other listed tissues and are recessive visible, female mating defective, (with alex) visible and (with Df(2L)al) visible. al is discussed in 96 references (excluding sequence accessions), dated between 1925 and 2003. These include at least 6 studies of mutant phenotypes, one study of wild-type function and 4 molecular studies. Among findings on al function, in the leg, al is only required for the growth and differentiation of the tip of the leg and not for the formation of the proximo-distal axis.		FB	FBgn0000061
3683	Alas		;CG3017	Aminolevulinate synthase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Aminolevulinate synthase, abbreviated as Alas, is reported here. It encodes a product with 5-aminolevulinate synthase activity (EC:2.3.1.37) involved in amino acid metabolism which is a component of the mitochondrial matrix. It has been sequenced and its amino acid sequence contains an aminotransferases class-II and an aminolevulinic acid synthase domain. It has been mapped cytologically to 60A14. There are 2 recorded alleles: 1 classical mutant (available from the public stock centers) and 1 wild-type. Alas is discussed in 14 references (excluding sequence accessions), dated between 1994 and 2003. These include at least 4 molecular studies.		FB	FBgn0020764
3687	Aldh		ACDH;Acetaldehyde dehydrogenase;aldehyde dehydrogenase;CG3752	Acetaldehyde dehydrogenase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Acetaldehyde dehydrogenase, abbreviated as Aldh, is reported here. It encodes a product with aldehyde dehydrogenase (NAD) activity (EC:1.2.1.3) which is localized to the cytoplasm. There is one recorded allele, which is wild-type. Aldh is discussed in 9 references, dated between 1968 and 2002. These include at least one molecular study.		FB	FBgn0012036
3690	Alg10		;Alpha 3 glucosyltransferase;CG32076;CG7624	Alpha 3 glucosyltransferase	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Alpha 3 glucosyltransferase, abbreviated as Alg10, is reported here. It has also been known in FlyBase as CG7624. It encodes a product with glucosyltransferase activity (EC:2.4.1.-) involved in N-linked glycosylation which is a component of the endoplasmic reticulum. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 68A9. There is one recorded allele, which is wild-type. Alg10 is discussed in 3 references (excluding sequence accessions), dated between 1999 and 2002. These include at least one molecular study.		FB	FBgn0052076
3691	Alhambra		AF10;Alh;Alhamabra;anon-WO0118547.226;CG1070;Dalf;l(3)j13A6;l(3)j8C8	Alhambra	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Alhambra is reported here. It has also been known in FlyBase as CG1070. It encodes a product with transcription factor activity involved in molting cycle (sensu Insecta) which is a component of the nucleus. It has been sequenced and its amino acid sequence contains a PHD-finger. It has been mapped cytologically to 84B6--C3. There are 8 recorded alleles: 2 in vitro constructs (none available from the public stock centers), 5 classical mutants (none available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the larva and the larval nervous system and are recessive developmental rate defective. Alhambra is discussed in 10 references (excluding sequence accessions), dated between 1999 and 2003. These include at least one molecular study.		FB	FBgn0037471
3692	alien		Alien;BcDNA:LD10463;CG9556;CH2;COP9 complex homolog subunit 2;CSN2;d-Alien;DCH2;Drosophila COP9 signalosome homolog 2	alien	fruit fly	Drosophila	melanogaster	The D. melanogaster gene alien is reported here. It has also been known in FlyBase as BcDNA:LD10463 and CH2. It encodes a product with transcription corepressor activity involved in negative regulation of transcription, DNA-dependent which is localized to the cytoplasm; it is expressed in the embryo (abdominal 1 intersegmental apodeme, abdominal 1 intrasegmental apodeme 1, abdominal 1 intrasegmentalapodeme 2, abdominal 2 intersegmental apodeme and 20 other listed tissues). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 29F7. There is one recorded allele, which is wild-type. alien is discussed in 22 references (excluding sequence accessions), dated between 1995 and 2003. These include at least one study of wild-type function and 6 molecular studies.		FB	FBgn0013746
3693	Alk		;CG8250;DAlk;DAlk53;mili		fruit fly	Drosophila	melanogaster	The D. melanogaster gene Alk is reported here. It has also been known in FlyBase as CG8250. It encodes a product with protein-tyrosine kinase activity (EC:2.7.1.112) involved in protein amino acid phosphorylation which is a component of the plasma membrane. It has been sequenced and its amino acid sequence contains an eukaryotic protein kinase, a MAM domain, a tyrosine kinase catalytic domain and a receptor tyrosine kinase class II. It has been mapped cytologically to 53C10. There are 6 recorded alleles: 5 in vitro constructs (none available from the public stock centers) and 1 wild-type. Alk is discussed in 15 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 2 molecular studies.		FB	FBgn0040505
3695	&alpha;-catenin-related		alpha-catenin-related;CG2987		fruit fly	Drosophila	melanogaster	The D. melanogaster gene alpha-catenin-related is reported here. It has also been known in FlyBase as CG2987. It encodes a product with actin binding putatively involved in cell adhesion which is a component of the zonula adherens. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 60A14. There is one recorded allele, which is wild-type. alpha-catenin-related is discussed in 7 references (excluding sequence accessions), dated between 1999 and 2003.		FB	FBgn0029105
3697	aly		;BcDNA:LD24793;cg1101;CG2075;dmREF1;l(3)02267;ms(3)2;ms(3)ry2;ref1	always early	fruit fly	Drosophila	melanogaster	The D. melanogaster gene always early, abbreviated as aly, is reported here. It has also been known in FlyBase as CG2075, ms(3)2 and ms(3)ry2. It encodes a product involved in spermatogenesis which is a component of the cytoplasm. It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 3-4.4 and cytologically to 63A3. It interacts genetically with comr. There are 13 recorded alleles: 12 classical mutants (1 available from the public stock centers) and 1 wild-type. Mutations have been isolated which affect the conditional ts testis and the conditional ts spermatocyte and are recessive male sterile and recessive meiotic. aly is discussed in 37 references (excluding sequence accessions), dated between 1982 and 2003. These include at least 4 studies of mutant phenotypes, 3 studies of wild-type function and 3 molecular studies. Among findings on aly mutants, mutations of aly affect the morphology and behavior of the mitotic spindles of embryonic cleavage divisions to produce multipolar spindles in male meiosis and generate abnormal mitotic figures in larval neuroblasts. Among findings on aly function, aly may regulate cell cycle progression and terminal differentiation during male gametogenesis by regulating chromatin conformation in primary spermatocytes.		FB	FBgn0004372
3699	Ama		AMA;amalgam;BG:DS00276.6;CG2198;CT7244;M109	Amalgam	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Amalgam, abbreviated as Ama, is reported here. It has also been known in FlyBase as M109. It encodes a product with antigen binding involved in cell adhesion which is localized to the plasma membrane; it is expressed in the embryo (amnioserosa, embryonic central nervous system, embryonic/larval dorsal vessel, fat body and 7 other listed tissues). It has been sequenced and its amino acid sequence contains an immunoglobulin and major histocompatibility complex domain, an immunoglobulin C-2 type and an immunoglobulin-like. It has been mapped cytologically to 84A5. It interacts genetically with Abl. There are 3 recorded alleles: 1 in vitro construct (not available from the public stock centers), 1 classical mutant (not available from the public stock centers) and 1 wild-type. Ama is discussed in 38 references (excluding sequence accessions), dated between 1988 and 2003. These include at least 2 studies of mutant phenotypes, 2 studies of wild-type function and 5 molecular studies.		FB	FBgn0000071
3704	amos		Amos;asolo;CG10393;Roi;rolo;Rough eye;Tft;Tufted	absent MD neurons and olfactory sensilla	fruit fly	Drosophila	melanogaster	The D. melanogaster gene absent MD neurons and olfactory sensilla, abbreviated as amos, is reported here. It has also been known in FlyBase as Roi, Tft and rolo. It encodes a product with transcription factor activity involved in sensory organ determination which is a component of the nucleus; it is expressed in the embryo (abdominal segment, antenno-maxillary complex, cellular blastoderm, embryonic antennal segment and 5 other listed tissues), ovary (centripetally migrating follicle cell, nurse cell and oocyte) and prepupa and pupa (antennal disc, olfactory sensory organ and tarsus). It has been sequenced and its amino acid sequence contains a helix-loop-helix dimerization domain. It has been mapped by recombination to 2-53.6 and cytologically to 36F6. It interacts genetically with da, hh, ro, ato, Dr and 9 other listed genes. There are 11 recorded alleles: 3 in vitro constructs (none available from the public stock centers), 5 classical mutants (2 available from the public stock centers) and 3 wild-type. Hypomorphic mutations have been isolated which affect the dorsal abdominal cluster, the dorsal multidendritic neuron and the abdominal dorsal bipolar neuron dbp and are recessive lethal. amos is discussed in 47 references (excluding sequence accessions), dated between 1952 and 2003. These include at least 8 studies of mutant phenotypes, 3 studies of wild-type function and 4 molecular studies. Among findings on amos function, amos is a proneural gene for olfactory sensilla, most likely the sensilla basiconica and trichodea.		FB	FBgn0003270
3705	Amph		Amp;amphiphysin;CG8604;DAMP;damph	Amphiphysin	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Amphiphysin, abbreviated as Amph, is reported here. It has also been known in FlyBase as Amp, amph and amphiphysin. It encodes a product involved in protein localization which is a component of the synapse. It has been sequenced and its amino acid sequence contains an amphiphysin. It has been mapped cytologically to 49B7--8. It interacts genetically with bif. There are 15 recorded alleles: 2 in vitro constructs (none available from the public stock centers), 11 classical mutants (2 available from the public stock centers) and 2 wild-type. Mutations have been isolated which affect the larval neuromuscular junction, the rhabdomere, the motor neuron and the indirect flight muscle and are viable, flightless, larval hypoactive and larval neurophysiology defective. Amph is discussed in 31 references (excluding sequence accessions), dated between 1999 and 2003. These include at least one study of mutant phenotypes, one study of wild-type function and 6 molecular studies. Among findings on Amph function, Amph is involved in the structural organization of the membrane-bound compartments of the excitation-contraction coupling machinery of muscles, but not in synaptic vesicle endocytosis.		FB	FBgn0027356
3706	amx		;BcDNA:GH02974;CG12127;fs(1)amx	almondex	fruit fly	Drosophila	melanogaster	The D. melanogaster gene almondex, abbreviated as amx, is reported here. It has also been known in FlyBase as BcDNA:GH02974. It encodes a product with putative endodeoxyribonuclease activity involved in mesoderm development which is putatively a component of the plasma membrane. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 8D10. There are 2 recorded alleles: 1 classical mutant (available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the eye, the thorax, the rescuable maternal effect epidermis and 6 other listed tissues and are recessive visible, rescuable maternal effect lethal, recessive female sterile and embryonic neurogenic (with Df(1)10-70d) lethal. amx is discussed in 32 references (excluding sequence accessions), dated between 1956 and 2003. These include at least 3 studies of mutant phenotypes, 2 studies of wild-type function and one molecular study.		FB	FBgn0000077
3717	And		ACaM;Calmodulin-related 97A;Camr97A;Camr97A: Calmodulin-related 97A;CG17769	Androcam	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Androcam, abbreviated as And, is reported here. It has also been known in FlyBase as CG17769 and Camr97A. It encodes a product with calcium ion binding involved in calcium ion sensing which is a component of the cytoplasm. It has been sequenced and its amino acid sequence contains a EF-hand family. It has been mapped cytologically to 96F3. There is one recorded allele, which is wild-type. And is discussed in 23 references (excluding sequence accessions), dated between 1994 and 2003. These include at least one study of wild-type function and 6 molecular studies. Among findings on And function, And may have a role in spermatogenesis and mature sperm function.		FB	FBgn0011273
3718	Ank		ANK;ankyrin;CG1651;CG32008;Dank1	Ankyrin	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Ankyrin, abbreviated as Ank, is reported here. It encodes a product with structural constituent of cytoskeleton involved in cytoskeletal anchoring which is localized to the plasma membrane; it is expressed in the larva (plasma membrane) and ovary (follicle cell, ovary and spectrosome). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 102A4--6. There are 3 recorded alleles: 2 in vitro constructs (none available from the public stock centers) and 1 wild-type. Ank is discussed in 49 references (excluding sequence accessions), dated between 1993 and 2003. These include at least 5 molecular studies.		FB	FBgn0011747
3719	Ank2		;CG7462;Dank2;ESTS:149B10S		fruit fly	Drosophila	melanogaster	The D. melanogaster gene Ank2 is reported here. It has also been known in FlyBase as ESTS149B10S and ESTS:149B10S. It encodes a product with structural constituent of cytoskeleton involved in cytoskeletal anchoring which is putatively a component of the plasma membrane. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 66A10. There is one recorded allele, which is wild-type. Ank2 is discussed in 16 references (excluding sequence accessions), dated between 1994 and 2003. These include at least 2 molecular studies.		FB	FBgn0017645
3727	anon-EST:Liang-1.56		;clone 1.56		fruit fly	Drosophila	melanogaster	The D. melanogaster gene anon-EST:Liang-1.56 is reported here. It has also been known in FlyBase as anon-1.56. It encodes a product with putative structural constituent of ribosome putatively involved in protein biosynthesis which is putatively a component of the cytosolic small ribosomal subunit (sensu Eukarya). It has been sequenced. There is one recorded allele, which is wild-type. anon-EST:Liang-1.56 is discussed in 2 references (excluding sequence accessions), dated between 1998 and 1999.		FB	FBgn0025982
3728	anon-EST:Liang-1.80		;clone 1.80		fruit fly	Drosophila	melanogaster	The D. melanogaster gene anon-EST:Liang-1.80 is reported here. It has also been known in FlyBase as anon-1.80. It encodes a product putatively involved in smooth muscle contraction which is putatively a component of the striated muscle thin filament. It has been sequenced. There is one recorded allele, which is wild-type. anon-EST:Liang-1.80 is discussed in 2 references (excluding sequence accessions), dated between 1998 and 1999.		FB	FBgn0025973
3731	anon-EST:Posey204				fruit fly	Drosophila	melanogaster	The D. melanogaster gene anon-EST:Posey204 is reported here. It has also been known in FlyBase as anon-ESTPosey204. It encodes a product with structural constituent of ribosome involved in protein biosynthesis which is a component of the cytosolic large ribosomal subunit (sensu Eukarya). It has been sequenced. There is one recorded allele, which is wild-type.		FB	FBgn0025305
3732	anon-EST:Posey37				fruit fly	Drosophila	melanogaster	The D. melanogaster gene anon-EST:Posey37 is reported here. It encodes a product with structural constituent of ribosome involved in protein biosynthesis which is a component of the cytosolic large ribosomal subunit (sensu Eukarya). It has been sequenced. There is one recorded allele, which is wild-type.		FB	FBgn0026273
3733	anon-EST:Posey6				fruit fly	Drosophila	melanogaster	The D. melanogaster gene anon-EST:Posey6 is reported here. It has also been known in FlyBase as anon-ESTPosey6. It encodes a product with putative structural constituent of ribosome putatively involved in protein biosynthesis which is putatively a component of the cytosolic ribosome (sensu Eukarya). It has been sequenced. There is one recorded allele, which is wild-type.		FB	FBgn0025288
3734	anon-MMS23		;S11		fruit fly	Drosophila	melanogaster	The D. melanogaster gene anon-MMS23 is reported here. It encodes a product with putative structural constituent of ribosome putatively involved in protein biosynthesis which is putatively a component of the cytosolic small ribosomal subunit (sensu Eukarya). There is one recorded allele, which is wild-type. anon-MMS23 is discussed in 2 references, dated between 1997 and 2002. These include at least one study of wild-type function.		FB	FBgn0025784
3737	Ant2		Adenine nucleotide translocase 2;ADP/ATP translocase.;CG1683;l(1)G0126;l(1)G0247;l(1)G0386	Adenine nucleotide translocase 2	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Adenine nucleotide translocase 2, abbreviated as Ant2, is reported here. It has also been known in FlyBase as l(1)G0126, l(1)G0247 and l(1)G0386. It encodes a product with ATP:ADP antiporter activity involved in ATP/ADP exchange which is a component of the mitochondrial inner membrane. It has been sequenced and its amino acid sequence contains a mitochondrial energy transfer proteins (carrier protein), a mitochondrial carrier domain and an adenine nucleotide translocator 1. It has been mapped cytologically to 9E10. There are 10 recorded alleles: 1 in vitro construct (not available from the public stock centers), 8 classical mutants (1 available from the public stock centers) and 1 wild-type. Ant2 is discussed in 19 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 3 molecular studies.		FB	FBgn0025111
3739	Antp		3.4;Ant;ANT-C;ANT-P;ANTC;antp;Antp1;BG:DS07700.1;CG1028;DmAntp;DMANTPE1;DRO15DC96Z;Hu;Hu: Humeral;Humeral;l(3)84Ba;Nasobemia;Ns;Ns: Nasobemia;Scx;Scx: Sex combs extra;Sex comb extra;Sex combs extra	Antennapedia	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Antennapedia, abbreviated as Antp, is reported here. It has also been known in FlyBase as MS:Antp.3.4. It encodes a product with specific RNA polymerase II transcription factor activity involved in regulation of transcription from Pol II promoter which is localized to the nucleus; it is expressed in the embryo (ectoderm, embryonic abdominal neuromere, embryonic abdominal segment 1 to 7, embryonic central nervous system and 21 other listed tissues) and larva (dorsal mesothoracic disc, dorsal metathoracic disc, dorsal pouch, dorsal prothoracic disc and 9 other listed tissues). It has been sequenced and its amino acid sequence contains a homeobox domain and a 'Homeobox' antennapedia-type domain. It has been mapped by recombination to 3-47.5 and cytologically to 84B1--2. It interacts genetically with Pc, brm, Pcl, Ubx, osa and 29 other listed genes. There are 136 recorded alleles: 41 in vitro constructs (1 available from the public stock centers), 94 classical mutants (64 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone mesothoracic leg, the ectopic somatic clone antenna, the somatic clone macrochaeta and 5 other listed tissues and are somatic clone visible. Antp is discussed in 619 references (excluding sequence accessions), dated between 1916 and 2003. These include at least 109 studies of mutant phenotypes, 7 studies of wild-type function, one study of natural polymorphisms and 32 molecular studies. Among findings on Antp mutants, mutations of Antp cause abnormal leg development or thoracic development or both. (However, there is much more information on mutants so that may not be representative.)		FB	FBgn0000095
3741	aop		Aop;Aop/Yan;CG3166;DROYANET;DROYANETSB;pok;pok: pokkuri;pokkuri;SK2-1;yan;yan/pok;yan: yan	anterior open	fruit fly	Drosophila	melanogaster	The D. melanogaster gene anterior open, abbreviated as aop, is reported here. It has also been known in FlyBase as MS:DROYANET. It encodes a product with specific RNA polymerase II transcription factor activity involved in induction of apoptosis which is localized to the nucleus; it is expressed in the embryo (embryonic/larval tracheal system and epidermis), larva (eye-antennal disc and imaginal disc) and prepupa and pupa (cone cell and pigment cell). It has been sequenced and its amino acid sequence contains an ets-domain, a HSF/ETS DNA-binding domain and a sterile &alpha; motif (SAM)/Pointed domain. It has been mapped by recombination to 2-12 and cytologically to 22D1. It interacts genetically with Ras85D, phl, rl, ttk, ksr and 48 other listed genes. There are 52 recorded alleles: 22 in vitro constructs (6 available from the public stock centers), 29 classical mutants (2 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the (with aoppok-x8) ommatidium, the (with aoppok-x8) eye, the chordotonal organ and 5 other listed tissues and are recessive embryonic lethal, (with aoppok-x8) lethal, (with aoppok-x8) visible and neuroanatomy defective. aop is discussed in 204 references (excluding sequence accessions), dated between 1984 and 2003. These include at least 33 studies of mutant phenotypes, 14 studies of wild-type function, one study of natural polymorphisms and 9 molecular studies. Among findings on aop function, map kinase mediated down-regulation of aop function appears to be critical for the proper differentiation of both neuronal and nonneuronal tissues throughout development.		FB	FBgn0000097
3742	Aos1		;CG12276;DmAos1;DmSAE1;SAE1;Smt3 activating enzyme 1;Ubiquitin activating enzyme		fruit fly	Drosophila	melanogaster	The D. melanogaster gene Aos1 is reported here. It has also been known in FlyBase as CG12276 and SAE1. It encodes a product with SUMO activating enzyme activity involved in SMT3-dependent protein catabolism. It has been sequenced and its amino acid sequence contains a UBA/THIF-type NAD/FAD binding fold. It has been mapped cytologically to 87B10. There are 2 recorded alleles: 1 in vitro construct (not available from the public stock centers) and 1 wild-type. Aos1 is discussed in 15 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 5 molecular studies.		FB	FBgn0029512
3743	ap		;blt;CG8376;LIM;no-wings;tornwing;trw;trw: tornwing;Xa;Xa: Xasta;Xasta	apterous	fruit fly	Drosophila	melanogaster	The D. melanogaster gene apterous, abbreviated as ap, is reported here. It encodes a product with zinc ion binding involved in neurogenesis which is localized to the nucleus; it is expressed in the embryo (chordotonal organ, embryonic brain, embryonic central nervous system, embryonic mandibular segment and 10 other listed tissues) and larva (dorsal mesothoracic disc, dorsal metathoracic disc, eye-antennal disc, larval brain and 4 other listed tissues). It has been sequenced and its amino acid sequence contains a homeobox domain. It has been mapped by recombination to 2-55.2 and cytologically to 41F8. It interacts genetically with Chi, fng, Bx, Ser, wg and 12 other listed genes. There are 90 recorded alleles: 25 in vitro constructs (none available from the public stock centers), 64 classical mutants (10 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the haltere, the embryonic/larval somatic muscle, the abdominal 2 to 7 lateral transverse muscle 1 to 3 and 8 other listed tissues and are (with apmd544) visible and (with apmd544) neuroanatomy defective. ap is discussed in 319 references (excluding sequence accessions), dated between 1914 and 2003. These include at least 39 studies of mutant phenotypes, 17 studies of wild-type function and 18 molecular studies. Among findings on ap mutants, a group of ap alleles, represented by apblt, exhibits a less severe, somewhat different wing phenotype than ap1 or ap4, attributable to localized lysosomal cell death in the presumptive wing blade. Among findings on ap function, ap mediates development of direct flight muscles autonomously and development of indirect flight muscles through epidermal cues. (However, there is much more information on function so that may not be representative.)		FB	FBgn0000099
3746	AP-2		;CG7807;DAP-2;dAP-2&agr;;dAP-2alpha;stummelbein		fruit fly	Drosophila	melanogaster	The D. melanogaster gene AP-2 is reported here. It encodes a product with specific RNA polymerase II transcription factor activity involved in leg joint morphogenesis (sensu Holometabola) which is a component of the nucleus; it is expressed in the embryo (embryonic protocerebrum, embryonic protocrebral neuromere, embryonic/larval brain, procephalic neurectoderm and 2 other listed tissues) and larva (eye-antennal disc, larval optic lobe, ventral nerve cord and ventral thoracic disc). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 78D8--E1. There are 22 recorded alleles: 2 in vitro constructs (none available from the public stock centers), 19 classical mutants (none available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the leg, the joint, the proboscis and 3 other listed tissues and are adult recessive lethal and dominant visible. AP-2 is discussed in 15 references (excluding sequence accessions), dated between 1997 and 2004. These include at least one study of wild-type function and 2 molecular studies.		FB	FBgn0023417
3751	Apc		adenomatous polyposis coli;APC;APC-like;APC1;CG1451;D-APC;D-APC1;dApc;dAPC1	APC-like	fruit fly	Drosophila	melanogaster	The D. melanogaster gene APC-like, abbreviated as Apc, is reported here. It has also been known in FlyBase as CG1451. It encodes a product with beta-catenin binding involved in negative regulation of transcription, DNA-dependent which is a component of the apicolateral plasma membrane; it is expressed in the embryo (axon, embryonic nervous system, epidermis, longitudinal connectives and 2 other listed tissues). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 98E5--6. It interacts genetically with Apc2, arm, pan and sgg. There are 6 recorded alleles: 1 in vitro construct (not available from the public stock centers), 4 classical mutants (1 available from the public stock centers) and 1 wild-type. Mutations have been isolated which affect the photoreceptor cell R1 to 8 and the photoreceptor cell and are recessive conditional ts lethal and viable. Apc is discussed in 86 references (excluding sequence accessions), dated between 1996 and 2003. These include at least 6 studies of mutant phenotypes, 2 studies of wild-type function and 5 molecular studies.		FB	FBgn0015589
3752	Apc2		APC;APC2;CG6193;D-APC2;dApc2;dAPC2/E-APC;DE-Cadherin;E-APC;E-APC dAPC2;E-APC: Epithelial Adenomatous Polyposis Coli;Epithelial Adenomatous Polyposis Coli	Adenomatous polyposis coli tumor suppressor homolog 2	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Adenomatous polyposis coli tumor suppressor homolog 2, abbreviated as Apc2, is reported here. It encodes a product with putative microtubule binding involved in Wnt receptor signaling pathway which is a component of the apicolateral plasma membrane. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 95E6. It interacts genetically with Apc and wg. There are 12 recorded alleles: 5 in vitro constructs (none available from the public stock centers), 6 classical mutants (3 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the wing vein, the ommatidium, the chaeta and 6 other listed tissues and are (with Apc2&delta;S) sterile, viable, recessive visible, recessive sterile and embryonic recessive maternal effect lethal. Apc2 is discussed in 68 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 6 studies of mutant phenotypes, one study of wild-type function and 5 molecular studies.		FB	FBgn0026598
3757	Aph-1		Alkaline phosphatase;AP;APH;CG2855;Dm APH-1;l(2)23AB6;l(2)23Ag;l-Aph;larval Alkaline phosphatase;p-Aph;pen-1;presenilin enhancer-1;presenilin stabilization factor;pupal Alkaline phosphatase	Alkaline phosphatase 1	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Alkaline phosphatase 1, abbreviated as Aph-1, is reported here. It encodes a product with alkaline phosphatase activity (EC:3.1.3.1). It has been mapped by recombination to 3-47.3. There are 7 recorded alleles, all wild-type. Aph-1 is discussed in 17 references, dated between 1964 and 2003. These include at least one study of natural polymorphisms.		FB	FBgn0000106
3758	aph-1		Aph-1;CG2855;Dm APH-1;pen-1;pen-1:presenilin stabilization factor;presenilin enhancer-1	anterior pharynx defective 1	fruit fly	Drosophila	melanogaster	The D. melanogaster gene anterior pharynx defective 1, abbreviated as aph-1, is reported here. It has also been known in FlyBase as CG2855 and pen-1. It encodes a product with endopeptidase activity involved in Notch signaling pathway which is a component of the integral to plasma membrane. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 23A5. There are 3 recorded alleles: 2 in vitro constructs (none available from the public stock centers) and 1 wild-type. aph-1 is discussed in 7 references (excluding sequence accessions), dated between 2000 and 2003. These include at least 2 molecular studies.		FB	FBgn0031458
3761	Aph-4		Alkaline phosphatase;Alkaline phosphatase-4;AP;Aph;CG1462;l(3)07028;pMY51	Alkaline phosphatase 4	fruit fly	Drosophila	melanogaster	The D. melanogaster gene Alkaline phosphatase 4, abbreviated as Aph-4, is reported here. It has also been known in FlyBase as l(3)07028. It encodes a product with alkaline phosphatase activity (EC:3.1.3.1) involved in neurogenesis which is a component of the extrinsic to plasma membrane, GPI-anchored; it is expressed in the adult (Malpighian tubule and ellipsoid body). It has been sequenced and its amino acid sequence contains an alkaline phosphatase family. It has been mapped cytologically to 100B1. There are 4 recorded alleles: 3 classical mutants (1 available from the public stock centers) and 1 wild-type. Mutations have been isolated which affect the adult Malpighian tubule and are viable. Aph-4 is discussed in 13 references (excluding sequence accessions), dated between 1990 and 2003. These include at least one study of natural polymorphisms and 5 molecular studies.		FB	FBgn0016123
3764	aPKC		;aPKC-zeta;atypical protein kinase C;CG10261;DaPKC;i;l(2)k06403;pkc-3;PKCl;PKCl,i;pschur;psu	atypical protein kinase C	fruit fly	Drosophila	melanogaster	The D. melanogaster gene atypical protein kinase C, abbreviated as aPKC, is reported here. It has also been known in FlyBase as CG10261 and l(2)k06403. It encodes a product with protein serine/threonine kinase activity involved in oocyte cell fate determination (sensu Insecta) which is a component of the apical cortex. It has been sequenced and its amino acid sequence contains an eukaryotic protein kinase, a protein kinase C-terminal domain, a phorbol esters/diacylglycerol binding domain and a serine/Threonine protein kinase family active site. It has been mapped cytologically to 51D5--6. It interacts genetically with orb. There are 10 recorded alleles: 6 in vitro constructs (none available from the public stock centers), 3 classical mutants (2 available from the public stock centers) and 1 wild-type. Mutations have been isolated which affect the ventral embryonic/first instar larval cuticle, the (with Df(2R)Jp1) embryonic/first instar larval cuticle, the embryonic head and 6 other listed tissues and are recessive lethal, embryonic (with Df(2R)Jp1) lethal and somatic clone cell polarity. aPKC is discussed in 74 references (excluding sequence accessions), dated between 1994 and 2003. These include at least 2 studies of mutant phenotypes, one study of wild-type function and 5 molecular studies. Among findings on aPKC mutants, a loss of function mutation in aPKC results in loss of apico-basal polarity and multilayering of epithelia in the embryo.		FB	FBgn0022131
3767	Appl		&bgr;-amyloid-protein-precursor-like;A&bgr;;Abeta;APP;appl;BcDNA:GH04413;beta-amyloid-protein-precursor-like;CG6666;CG7727;EG:65F1.5	&beta; amyloid protein precursor-like	fruit fly	Drosophila	melanogaster	The D. melanogaster gene &beta; amyloid protein precursor-like, abbreviated as Appl, is reported here. It has also been known in FlyBase as BcDNA:GH04413. It encodes a product with putative receptor activity involved in neurogenesis which is localized to the axon and the plasma membrane; it is expressed in the adult (Kenyon cell, adult brain, head, lobe of mushroom body and 2 other listed tissues), embryo (embryonic central nervous system, longitudinal connectives, peripheral nervous system, ventral nerve cord commissure and 2 other listed tissues), larva (axon, eye-antennal disc, larval brain, larval central nervous system and 7 other listed tissues) and prepupa and pupa (lamina, lobula, medulla neuropil, lamina and 4 other listed tissues). It has been sequenced and its amino acid sequence contains an amyloidogenic glycoprotein (Amyloid A4). It has been mapped by recombination to 1-0.0 and cytologically to 1B9--10. It interacts genetically with Khc and Sh. There are 17 recorded alleles: 12 in vitro constructs (none available from the public stock centers), 4 classical mutants (none available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the bouton and the larval nervous system and are visual behavior defective, viable, fertile and neuroanatomy defective. Appl is discussed in 52 references (excluding sequence accessions), dated between 1989 and 2003. These include at least 3 studies of mutant phenotypes, 2 studies of wild-type function and 13 molecular studies. Among findings on Appl function, Appl promotes synapse differentiation at the neuromuscular junction.		FB	FBgn0000108
3769	apt		3041;CG5393;l(2)03041;l(2)06369;l(2)09049;l(2)59Ea;l(2)k11531;tdf;TDF/APT;Trachea defective;tracheae defective	apontic	fruit fly	Drosophila	melanogaster	The D. melanogaster gene apontic, abbreviated as apt, is reported here. It has also been known in FlyBase as l(2)03041, l(2)06369, l(2)09049, l(2)k11531 and tdf. It encodes a product with RNA binding involved in negative regulation of oskar mRNA translation which is localized to the nucleus; it is expressed in the embryo (acron, amnioserosa, cardioblast, dorsal vessel primordium and 14 other listed tissues) and ovary (follicle cell, nurse cell and oocyte). It has been sequenced and its amino acid sequence contains a myb DNA binding domain. It has been mapped cytologically to 59F1--4. It interacts genetically with Dfd and aret. There are 21 recorded alleles: 3 in vitro constructs (none available from the public stock centers), 17 classical mutants (2 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the embryonic/larval trachea and are recessive lethal. apt is discussed in 57 references (excluding sequence accessions), dated between 1990 and 2003. These include at least 4 studies of mutant phenotypes, 2 studies of wild-type function and 8 molecular studies. Among findings on apt function, apt is required for morphogenesis and function of the heart.		FB	FBgn0015903
3773	ara		;CG10571;Iro;IRO-C;Iroquis complex;Iroquois;iroquois gene complex;iroquois-complex	araucan	fruit fly	Drosophila	melanogaster	The D. melanogaster gene araucan, abbreviated as ara, is reported here. It has also been known in FlyBase as iro. It encodes a product with transcription factor activity involved in wing vein specification which is a component of the nucleus; it is expressed in the embryo (embryonic/larval proventriculus, epidermis and procephalic segment) and larva (alula, dorsal metathoracic disc, imaginal disc, larval ventral ganglion and 5 other listed tissues). It has been sequenced and its amino acid sequence contains a homeobox domain and an iroquois-class homeodomain protein motif. It has been mapped cytologically to 69C8--10. It interacts genetically with mirr, ph-d, Sce, Pc, Pcl and 9 other listed genes. There are 13 recorded alleles: 2 in vitro constructs (none available from the public stock centers), 10 classical mutants (none available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the macrochaeta, the microchaeta, the mesothoracic segment and 4 other listed tissues and are viable, visible, recessive female sterile, recessive male sterile and (with ararF209) visible. ara is discussed in 93 references (excluding sequence accessions), dated between 1991 and 2003. These include at least 7 studies of mutant phenotypes, 4 studies of wild-type function and 5 molecular studies.		FB	FBgn0015904
3774	aralar1		;BcDNA:GH07418;CG2139;DmAralar		fruit fly	Drosophila	melanogaster	The D. melanogaster gene aralar1 is reported here. It has also been known in FlyBase as BcDNA:GH07418 and CG2139. It encodes a product with calcium ion binding involved in mitochondrial transport which is a component of the integral to membrane. It has been sequenced and its amino acid sequence contains a mitochondrial energy transfer proteins (carrier protein), a EF-hand family and a mitochondrial carrier domain. It has been mapped cytologically to 99F4--5. There are 2 recorded alleles: 1 classical mutant (not available from the public stock centers) and 1 wild-type. aralar1 is discussed in 16 references (excluding sequence accessions), dated between 1999 and 2003. These include at least 3 molecular studies.		FB	FBgn0028646
3776	Arc-p34		38C.47;anon-WO0118547.154;ARC-P34;Arpc2;ARPC2/p34;CG10954;p34		fruit fly	Drosophila	melanogaster	The D. melanogaster gene Arc-p34 is reported here. It has also been known in FlyBase as CG10954. It encodes a product with actin binding involved in regulation of actin polymerization and/or depolymerization which is a component of the Arp2/3 protein complex. It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 38C6. There are 2 recorded alleles: 1 classical mutant (available from the public stock centers) and 1 wild-type. Arc-p34 is discussed in 17 references (excluding sequence